Synthetic Studies on Rare and Novel Marine Diterpenes

海洋珍稀二萜类化合物的合成研究

• 批准号: 1148569
• 负责人: Gary Sulikowski
• 金额: $ 40万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1148569&HistoricalAwards=false
• 关键词: Synthetic; Studies; Rare; Novel; Marine

With this award, the Chemical Synthesis program is funding Professor Gary Sulikowski of the Department of Chemistry at Vanderbilt University to explore the development of synthetic methods to access structural complex and rare marine diterpene natural products. A number of complex marine diterpenes, such as bielschowskysin, display interesting biological activity (tumor cell growth inhibition, antimalarial properties), but are either no longer available from their natural source, or of limited availability. The unique molecular structure of bielschowskysin and related marine diterpenes requires the development of new methods and strategies to assemble its unique architecture.The broader impacts include co-worker training in a multi-disciplinary environment through the inclusion of biomedical researchers on the project, and continuing to build a program in the biological study of natural products. This work could lead to more efficient methods for the preparation of marine natural products. The chemistry developed during the course of these studies will have a broad impact in areas ranging from the pharmaceutical, chemical, and biotechnology industries to basic biological and chemical research endeavors. In addition, this project will provide excellent training of students, from undergraduate to post-doctoral, including those from groups historically underrepresented in the sciences.

通过这一奖项，化学合成项目资助了范德比尔特大学化学系的Gary Sulikowski教授，以探索获取结构复合物和稀有海洋二萜天然产物的合成方法的发展。许多复杂的海洋二萜，如bielschowskysin，显示出有趣的生物活性（肿瘤细胞生长抑制，抗疟疾特性），但要么不再从其天然来源获得，要么供应有限。bielschowskysin及其相关海洋二萜的独特分子结构要求开发新的方法和策略来组装其独特的结构。更广泛的影响包括通过将生物医学研究人员纳入项目，在多学科环境中对同事进行培训，并继续建立天然产物的生物学研究计划。这项工作可能会导致更有效的制备海洋天然产品的方法。在这些研究过程中发展的化学将在从制药，化学和生物技术工业到基础生物和化学研究的努力等领域产生广泛的影响。此外，该项目将为学生提供优秀的培训，从本科生到博士后，包括那些来自历史上在科学领域代表性不足的群体。