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Identification and Characterization of Functional Constraints Operating on the Gene Organization of the Drosophila Genome

果蝇基因组基因组织功能约束的鉴定和表征

基本信息

批准号：
1157876
负责人：
Jose Ranz
金额：
$ 80万
依托单位：
University of California-Irvine
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-15 至 2016-10-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1157876&HistoricalAwards=false
关键词：
Identification Characterization Functional Constraints Operating

项目摘要

This project will advance understanding of the relationship between the organization of genes on chromosomes and the probability of occurrence of macromutations that alter chromosomes. The organization of genes on chromosomes can be important for proper gene function, which sometimes requires the interplay of genetic factors far apart on the chromosome. Methods that enable the manipulation of fruit flies chromosomes will be used to test the consequences of induced rearrangements on the function of genes putatively under the influence of these long-range effects. This project aims at answering why particular regions of chromosomes have been conserved among distantly related species while others often exhibit an unusual association with macromutations.Broader Impacts: From the training standpoint, this project will help train one postdoc, six undergraduates, and six high-school students in the analysis of the function of genomes and evolutionary biology. Members of underrepresented groups will be preferentially benefited by the research activities to be developed. Participants will also have the opportunity to hone their presentation skills. In addition, specific activities in this project will be adapted and integrated into the teaching activities of the PI. All data and materials generated will be made publicly available to the scientific community and deposited in appropriate repositories.

该项目将加深对染色体上基因组织与改变染色体的大突变发生概率之间关系的理解。染色体上基因的组织对于基因的正常功能非常重要，有时需要染色体上相距较远的遗传因素相互作用。能够操纵果蝇染色体的方法将用于测试在这些远程效应的影响下诱导重排对基因功能的影响。该项目旨在回答为什么染色体的特定区域在远缘物种中是保守的，而其他区域往往与大突变表现出不寻常的关联。更广泛的影响：从培训的角度来看，该项目将帮助培训一名博士后、六名本科生和六名高中生进行基因组功能和进化生物学的分析。代表性不足群体的成员将优先受益于即将开展的研究活动。参与者还将有机会磨练他们的演讲技巧。此外，该项目中的具体活动将被调整并融入到 PI 的教学活动中。生成的所有数据和材料将向科学界公开，并存放在适当的存储库中。