Routes to UV Activated Fouling Reversal and Molecular Weight Cutoff Control in Tethered Micelle Ultrafiltration Membrane Assemblies

系留胶束超滤膜组件中紫外线激活污垢逆转和分子量截留控制的途径

• 批准号: 1160026
• 负责人: Travis Bailey
• 金额: $ 40万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1160026&HistoricalAwards=false
• 关键词: Routes; UV; Activated; Fouling; Reversal

1160026BaileyThis NSF award by the Chemical and Biological Separations program of the Chemical, Bionengineering, Environmental, and Transport Systems (CBET) Division and the Macromolecular, Supramolecular and Nanochemistry (MSN) Program of the Chemistry Division supports work by Professor Travis S. Bailey to develop new a new class of ultrafiltration membranes relevant to biological separations prevalent across a range of industries, particularly pharmaceutical processes involving antibody and protein based drug purification. In a recent article by Reuters published in April 2011, it was projected that as early as 2014, 8 of the 10 world?s top selling drugs will be antibody based biologics. Separations involving the manufacture of these biologics continue to represent a major fraction of the production cost, due to high costs of current membrane technologies (e.g. Protein A type columns), limited membrane lifetimes due to excessive fouling, and difficult integration into large scale purification process flows. In response to these fundamental challenges, this work explores a new approach to ultrafiltration membrane fabrication based on photoactive tethered micelle networks, assembled from nanostructured block copolymer assemblies. The principal objectives of the proposed research are to develop and validate the potential of this new class of ultrafiltration membranes to provide (1) high flux, (2) narrow and uniform pore size distributions, (3) user-enabled tuning of the molecular weight cutoff regimes and (4) built in fouling resistance and reversal capabilities. Cumulative energy (and therefore cost) savings associated with higher efficiency ultrafiltration processes would have worldwide impact, dramatically reducing purification processing costs associated with antibody and other protein based drugs being brought to market. Improved fouling resistance and effective reversal strategies would additionally extend the range of systems for which ultrafiltration is a viable separations solution.

1160026贝利这个NSF奖的化学和生物分离计划的化学，生物工程，环境和运输系统（CBET）司和大分子，超分子和纳米化学（MSN）计划的化学司支持教授特拉维斯S。贝利开发新的一类新的超滤膜相关的生物分离普遍存在于一系列行业，特别是制药过程涉及抗体和蛋白质为基础的药物纯化。路透社最近在2011年4月发表的一篇文章中预测，早在2014年，世界上10个国家中就有8个？最畅销的药物将是基于抗体的生物制剂。涉及这些生物制剂的制造的分离继续代表生产成本的主要部分，这是由于当前膜技术（例如蛋白A型柱）的高成本、由于过度污染而导致的有限的膜寿命以及难以整合到大规模纯化工艺流程中。为了应对这些根本性的挑战，这项工作探索了一种新的方法，超滤膜制造的基础上光活性拴系胶束网络，组装从纳米结构的嵌段共聚物组件。拟议研究的主要目标是开发和验证这种新型超滤膜的潜力，以提供（1）高通量，（2）窄而均匀的孔径分布，（3）用户启用的分子量截留制度的调整和（4）内置的抗污染性和逆转能力。与更高效率的超滤过程相关的累积能量（以及因此的成本）节省将具有世界范围的影响，显著降低与抗体和其他基于蛋白质的药物进入市场相关的纯化处理成本。改进的抗污染性和有效的逆转策略将另外扩展超滤作为可行的分离解决方案的系统的范围。