EAGER: Red Blood Cell Membrane Camouflaged Nanoparticles for Drug Delivery

ID: MPS/DMR/BMAT(7623) 1216461 PI: Zhang， Liangfang ORG: UC San diego gotle: EAGER：用于药物输送的红细胞膜伪装纳米颗粒知识价值：该奖项的研究目标是研究一种创新的仿生纳米颗粒平台，该平台使用天然红细胞（RBC）膜，而不是传统的合成隐身生物材料，来掩盖用于药物输送的合成纳米颗粒。所采取的方法将是利用一种新颖和革命性的自上而下的策略，通过将红细胞的整个细胞“实用涂层”转移到药物纳米载体的表面来功能化纳米颗粒。这样修饰的纳米粒子有望表现出与其源细胞相似的生理行为。为了实现主要目标，本项目将进行两项具体的研究任务：(i)研究RBC膜覆盖的聚合物纳米颗粒的物理化学和生物学特性；（ii）探索在RBC膜覆盖的纳米颗粒表面结合靶向配体的有效方法，以实现靶向药物递送。更广泛的影响：如果成功，该项目将开发出一种全新的仿生纳米颗粒，将红细胞膜与合成生物材料结合起来。这种天然细胞组分与合成生物材料的结合，为开发新型、强大的纳米给药载体提供了一种创新途径，将对生物材料研究和纳米给药领域产生深远影响。此外，这项工作将研究和教育高度结合。在这个项目期间，将进行两项教育重点：(i) PI将创建新的课程，以塑造和影响美国“纳米工程”的第一个本科课程的发展。该课程将作为其他机构开发类似课程的典范。（ii） PI将与加州大学圣地亚哥分校ET-CURE项目合作，为少数民族本科生提供刺激的研究经历。PI将招募1-2名少数民族本科生参与该项目。

ID: MPS/DMR/BMAT(7623) 1216461 PI: Zhang, Liangfang ORG: UC San DiegoTitle: EAGER: Red Blood Cell Membrane Camouflaged Nanoparticles for Drug DeliveryINTELLECTUAL MERIT: The research objective of this award is to study an innovative biomimetic nanoparticle platform that uses natural red blood cell (RBC) membranes, rather than conventional synthetic stealth biomaterials, to cloak synthetic nanoparticles for drug delivery. The approach taken will be to utilize a novel and revolutionary top-down strategy to functionalize nanoparticles by transferring the entire cellular 'utility coat' of an RBC onto the surface of drug nanocarriers. A nanoparticle thus modified is expected to exhibit similar physiologic behavior as its source cells. To achieve the primary goal, two specific research tasks will be pursued in the proposed project: (i) study the physicochemical and biological properties the RBC membrane cloaked polymeric nanoparticles, and (ii) explore effective approaches to incorporate targeting ligands on the surface of the RBC membrane cloaked nanoparticles for targeted drug delivery.BROADER IMPACTS: If successful, this project will develop an entirely new class of biomimetic nanoparticles that combines RBC membranes with synthetic biomaterials. Such a combination of natural cellular components with synthetic biomaterials presents an innovative approach to develop novel and powerful drug delivery nanocarriers and will have profound impacts on the fields of biomaterials research and nanotechnology drug delivery. Moreover, this work highly integrates research and education. Two education thrusts will be carried out during the period of this project: (i) The PI will create new courses to shape and impact the development of the first undergraduate curriculum in 'nanoengineering' in the Untitled States. This curriculum will be provided as a model for the development of similar programs at other institutions. (ii) The PI will collaborate with the UCSD ET-CURE Program to provide minority undergraduate students with stimulating research experiences. The PI will recruit 1-2 minority undergraduate students to work on this project.