NSF/FDA SIR: Quantitative Decision Analysis and Utility Assessments for Medical Imaging Technology

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ABSTRACT#1238502AbbeyThis proposal investigates the development and analysis of utility based measures of diagnosticperformance for the purpose of technology evaluation, using screening mammography as an example.This approach represents an important departure from the standard analysis, which uses receiver operatingcharacteristic (ROC) curve analysis to obtain area under the curve (AUC) as the study endpoint. Theutility methods confine attention to the most relevant part of the ROC curve. This leads to amore meaningful measure of performance, and also reduces sources of extraneous variabilityrelative to effect size, thereby leading to a more powerful statistical design of experiments.