Workshop: International Meeting on Protein Folding and Dynamics; to be held October 15-17, 2012 in Bangalore, India

该奖项是为了支持将于2012年10月15日至17日在印度班加罗尔的国际生物科学中心（NCBS）举行的为期两天的会议，题为“蛋白质折叠和动力学国际会议”。 会议的目的是汇集来自美国，欧洲和亚洲的科学家，讨论蛋白质折叠领域的最新进展和未来研究。此外，会议将作为一个开幕论坛，介绍一些新发起的机构（NCBS，慕尼黑技术大学和马里兰州大学）的活动到生命系统物理（POLS）网络。因此，这次会议承担了正式通知学生在NCBS的活动和POLS网络的好处的重要性。 在受邀的演讲者中，有几位也是网络节点的一部分。大约20位代表广泛专业知识和视野的研究人员将聚集在一起，以评估蛋白质折叠中的突出问题，以及这些问题如何与更大规模的功能相关。本次研讨会将召集约20名演讲者，他们代表蛋白质折叠的所有领域以及与蛋白质组装成更大的复合物和更高层次的组织结构相关的领域。生物学中的一个巨大挑战是将单个亚基水平的知识和能力与描述这些如何相互作用以影响细胞水平功能的能力相结合。 会议的主要目的是确定在未来十年中必须在理论，模拟和实验中解决的主要问题，以便蛋白质在细胞水平上发挥的作用，无论是一致的还是孤立的，都可以被评估和预测。会议将涵盖蛋白质折叠领域的主要未解决的问题，确定共同的主题，并制定一个如何整合单个亚基的行为来描述系统级现象的课程。更广泛的影响：这个研讨会是一种独特的方式，聚集了世界上一些领先的科学家，讨论在传统会议上从未深入讨论过的话题。 第二，思想交流对于确定新的研究领域至关重要，这些领域必须在不久的将来解决，因为我们为下一阶段的生物学定量研究开发了一种语言和框架。具有物理学、化学和生物学背景的广泛科学家将聚集在一起，确定必须解决的问题，并确定所需的方法。

This award is in support of a two-day meeting entitled "International Meeting on Protein Folding and Dynamics" to be held at the International Center for Biological Sciences (NCBS) in Bangalore, India, on October 15-17, 2012. The purpose of the meeting is to bring together scientists from the USA, Europe, and Asia to discuss recent advances and future research in the area of protein folding. In addition, the conference will serve as an inaugural forum for introducing some of the activities in the newly initiated institutions (NCBS, Technical University of Munich, and the University of Maryland) into the Physics of Living Systems (POLS) network. This conference, therefore, takes on the importance of formally informing the students in NCBS to the activities and benefits of the POLS network. Among the invited speakers several are also part of the Network nodes.About twenty researchers representing a broad range of expertise and vision will be assembled with the purpose of assessing the outstanding problems in folding of proteins, and how these are related to function at larger scales. This workshop will convene about 20 speakers that represent all areas of protein folding as well as areas related to the assembly of proteins into larger complexes and higher order organized structures. One of the great challenges in biology is to integrate knowledge and capabilities at the individual subunit level with the ability to describe how these interact to affect function at the cellular level. The major aim of the meeting is to identify major issues that must be addressed in theory, simulations, and experiments in the next decade so that the roles which proteins play to carry out the myriad functions at the cellular level, in concert and in isolation, can be assessed and predicted. The meeting will cover the major unsolved problems in the area of protein folding, identify common themes, and chart a course for how to integrate the behavior of individual subunits to describe phenomena at the systems level. Broader impacts: This workshop is a unique way to assemble some of the leading scientists in the world to discuss topics that are never discussed in such depth at traditional meetings. Second, the exchange of ideas will be crucial in identifying new areas of research, which have to be tackled in the immediate future as we develop a language and framework for the next phase of quantitative research in biology. A broad spectrum of scientists with backgrounds in physics, chemistry and biology will be brought together to define the issues that have to be tackled and to identify the approaches that are needed.