Conference: 2012 Intrinsically Disordered Proteins GRC; to be held July 8-13, 2012 in West Dover, VT

会议：2012 本质无序蛋白质 GRC；

• 批准号: 1242441
• 负责人: Rohit Pappu
• 金额: $ 1万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1242441&HistoricalAwards=false
• 关键词: Conference; 2012; Intrinsically; Disordered; Proteins

Intellectual Merit This is the second the Gordon Research Conference on Intrinsically Disordered Proteins (IDPs) to be held between July 08 and July 13, 2012. Biological functions are based on molecular recognition and complex networks are organized around a series of inter-related protein-protein and protein-nucleic acid interfaces. The traditional view posits that molecular recognition is achieved through a combination of shape complementarity and specific interactions between a protein and its binding partner. Traditional views are, however, being challenged by observations that roughly 30% of eukaryotic proteins fail to fold autonomously and their inability to fold is required for function. Such proteins, referred to as intrinsically disordered proteins or IDPs are implicated in a wide variety of functions that include fundamental processes in biology. IDPs add a new dimension to molecular recognition because they undergo large-scale conformational changes and they raise the question of how specificity in recognition is achieved despite the absence of precise pre-organized shape complementarity. This an opportune time to bring together scientists in the IDP field to identify the important questions, take stock of current progress, and chart the course for rapid and meaningful progress in the study of conformational heterogeneity and its role in protein function. The Gordon Conference on Intrinsically Disordered Proteins features an outstanding and diverse group of scientists at the forefront of research in the IDP field. The conference is organized around thematic sessions focusing on transcriptional regulation, signaling pathways and modules, IDP phase behavior and molecular recognition, emerging technologies for studying IDPs, IDP quality control and homeostasis, regulated self-assembly and mis-assembly of IDPs, and IDP targeting, trafficking and processing. Novel technological advances are needed to study IDPs therefore the conference will showcase the development of state-of-the art biophysical methods, advances in theory and computation, and the synergy with novel tools from molecular biology, for studying IDPs and developing a quantitative understanding regarding their functions in vivo. Broader ImpactThis Gordon Research Conference will promote research of IDPs at different levels and in various fields. The meeting has a highly relevant and synergistic focus on understanding the mechanisms by which IDPs function and the development of new integrated methods for studying and characterizing IDP form and function. In the final program, 12 of the 40 invited speakers and discussion leaders are women. The program has a balanced mixture of established and young scientists. Of the two program slots set aside for postdoctoral speakers, the conference chairs will strive to fill at least one with a woman / member of an under-represented minority community. The conference chairs will also ensure that at the stage of selection of participants in the meeting, minority participants will be selected to attend the meeting. When the attendees are selected from the pool of applicants, principles of affirmative action with respect to minority groups, women and junior scientists will be used as criteria, in addition to the date of application and the scientific background of the applicant.

这是第二次戈登研究会议上的内含子紊乱蛋白质（IDP）将于2012年7月8日至7月13日举行。生物学功能是以分子识别为基础的，复杂的网络是围绕一系列相互关联的蛋白质-蛋白质和蛋白质-核酸界面组织起来的。传统的观点认为，分子识别是通过形状互补性和蛋白质与其结合伴侣之间的特异性相互作用来实现的。然而，传统的观点受到了挑战，观察到大约30%的真核生物蛋白质不能自主折叠，它们不能折叠是功能所必需的。这种蛋白质，被称为内在无序蛋白质或IDP，涉及包括生物学中的基本过程在内的多种功能。IDPs增加了一个新的层面的分子识别，因为他们经历了大规模的构象变化，他们提出的问题是如何识别的特异性，尽管没有精确的预组织的形状互补性。这是一个合适的时机，汇集IDP领域的科学家，以确定重要的问题，评估目前的进展，并绘制路线，在构象异质性及其在蛋白质功能中的作用的研究快速和有意义的进展。戈登会议的内在无序蛋白具有在IDP领域的研究前沿的杰出和多样化的科学家群体。会议围绕转录调控、信号通路和模块、IDP阶段行为和分子识别、研究IDP的新兴技术、IDP质量控制和稳态、IDP的调节自组装和错误组装以及IDP的目标定位、贩运和处理等主题会议组织。研究IDPs需要新的技术进步，因此会议将展示最先进的生物物理方法的发展，理论和计算的进步，以及与分子生物学新工具的协同作用，用于研究IDPs并对其体内功能进行定量理解。更广泛的影响这次戈登研究会议将促进在不同层次和不同领域的国内流离失所者的研究。这次会议具有高度的相关性和协同作用，重点是了解国内流离失所者发挥作用的机制，并制定新的综合方法，研究和描述国内流离失所者的形式和功能。在最后一个方案中，40名受邀发言人和讨论领导人中有12名是妇女。该计划拥有成熟和年轻科学家的平衡混合。在为博士后演讲者预留的两个项目中，会议主席将努力填补至少一个代表性不足的少数民族社区的妇女/成员。会议主席还将确保在挑选与会者的阶段，少数群体与会者将被挑选出席会议。在从申请人中挑选与会者时，除了申请日期和申请人的科学背景外，还将使用对少数群体、妇女和青年科学家采取平权行动的原则作为标准。