Conference: 2012 FASEB Summer Research Conference on Virus Structure and Assembly to be held at the Vermont Academy, Saxtons River, Vermont

知识价值。2012年FASEB病毒结构和组装夏季研究会议将于2012年6月10日至6月15日在佛蒙特州萨克斯顿河的佛蒙特学院举行。会议将专门讨论病毒结构的最新发现，因为它涉及病毒诱导过程的机制，如进入、组装和核酸包装，以及它们在感染过程中与宿主的相互作用。感染性病毒的组装是一个复杂的过程，需要来自病毒和宿主的大量大分子的协调活动。病毒提供了极好的模型，以接近原子的分辨率来理解基本机制，这将对一般的生物系统产生广泛的影响。这最好通过包括遗传学、分子生物学、细胞生物学、结构、生化和生物物理学方法在内的多学科方法来实现。2012年会议的主题是“病毒分子机器”。讨论将集中在入口机、组装机、基因组包装机等的基本机制上。讲座将强调遗传学、分子病毒学、细胞生物学、生物物理病毒学和结构病毒学在许多病毒系统研究中的融合，许多病毒系统作为理解生物现象和其他与医学相关的重要模型。受邀演讲者将介绍用于研究病毒进入、退出、组装和宿主相互作用的关键步骤的各种方法。此外，会议还将讨论病毒结构确定领域的前沿发展，如单粒子电子显微图像重建、断层扫描、不对称重建和单分子方法。这个多层面的会议将作为一个论坛，整合来自许多病毒系统的研究成果，以基本理解病毒生命周期中的事件，从最初的宿主细胞受体附着和进入，细胞运输，基因组复制，病毒粒子组装/基因组包装，到病毒与宿主免疫机制的相互作用。更广泛的影响。会议将邀请年轻的研究人员、学生、博士后研究员、妇女和代表性不足的少数群体参与病毒结构和组装的前沿领域。为促进高级研究人员与研究生和博士后之间的直接科学交流，首次计划了特别行动。其中包括针对这些参与者的“与专家会面”、“前沿技术”和“网络”等特别会议。青年科学家也将有很多机会展示和讨论他们的工作。从摘要中选择的简短演讲将成为全体会议的一部分，这些演讲将由研究生和博士后研究员进行。海报会议将允许与来自多个学科的科学家深入讨论所呈现的数据。最后，会议的小规模和大量的讨论时间为年轻科学家提供了与更多资深研究人员广泛互动的绝佳机会。

Intellectual Merit. The 2012 FASEB Summer Research Conference on Virus Structure and Assembly will be held from June 10 to June 15, 2012, at the Vermont Academy, Saxtons River, Vermont. The meeting will be devoted to discussions of state-of-the-art findings on virus structure as it relates to the mechanisms of virus induced processes such as entry, assembly, and nucleic acid packaging, and their host interactions during the infectious process. The assembly of an infectious virus is a complex process that requires the coordinated activities of numerous macromolecules of both viral and host origin. Viruses provide excellent models to understand basic mechanisms at near atomic resolutions that will have broad implications to biological systems in general. This is best achieved by a multi-disciplinary approach that includes genetics, molecular biology, cell biology, and structural, biochemical and biophysical approaches. The theme of the 2012 conference is "Virus Molecular Machines". Discussions will focus on the basic mechanisms of entry machines, assembly machines, genome packaging machines, and so on. The talks will emphasize the convergence of genetics, molecular virology, cell biology, biophysical virology, and structural virology in the study of many viral systems, many serving as important models to understand biological phenomena and others with medical relevance. Invited speakers will present diverse approaches used to study the critical steps involved in virus entry, exit, assembly, and host interactions. In addition, the conference will address cutting edge developments in the areas of virus structure determination, such as single particle electron microscopic image reconstruction, tomography, asymmetric reconstruction and single molecule approaches. This multi-faceted conference will serve as a forum for integration of research findings from many viral systems towards fundamental understanding of the events in the viral life cycle, from the initial host cell receptor attachment and entry, cellular trafficking, genome replication, virion assembly/genome packaging, to interaction of viruses with the host immune machinery.Broader Impacts. The conference will engage young investigators, students, post-doctoral fellows, women and under-represented minorities in the cutting edge areas of virus structure and assembly. For the first time, special initiatives are planned for to foster direct scientific exchanges between senior investigators and graduate students and post-doctoral fellows. These include special sessions on "Meet the Experts," "Cutting Edge Technologies," and "Networking" that are geared to these participants. There will also be many opportunities for young scientists to present and discuss their work. Short talks chosen from the abstracts will be part of the plenary sessions and these will be given by graduate students and postdoctoral fellows. Poster sessions will allow for in-depth discussion of the presented data with scientists from multiple disciplines. Finally, the small size of the conference and the large amount of discussion time provides a wonderful opportunity for young scientists to have extensive interactions with more senior researchers.