SBIR Phase I: Production of an Acyl Glycinate Surfactant by Fermentation

SBIR 第一阶段：通过发酵生产酰基甘氨酸盐表面活性剂

• 批准号: 1248115
• 负责人: Kevin Jarrell
• 金额: $ 15万
• 依托单位: Modular Genetics, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1248115&HistoricalAwards=false
• 关键词: SBIR; Phase; Production; Acyl; Glycinate

This Small Business Innovative Research Phase I project is aimed at demonstrating that acyl glycinate surfactant can be produced by a novel bacterial fermentation route. The objective of this project is to construct a bacterial strain that produces acyl glycinate, and to provide a sample of that surfactant for commercial evaluation. A successful outcome will demonstrate that acyl glycine can be produced by fermentation. Surfactants are the bubbly components of cleaning products that give them their cleansing power. Surfactants are currently manufactured from petroleum or from seed oils, such as palm oil. The use of those raw materials increases greenhouse gas pollution and also leads to deforestation of rainforests. Retailers are demanding greener products, and regulatory agencies are demanding new minimally toxic chemicals. The demand for greener chemicals creates an opportunity to replace current surfactants with greener alternatives.The broader/commercial impact of the proposed innovation would be commercialization of the acyl glycinate surfactant. Additional benefits to society are that chemicals produced using this technology will be manufactured using domestically grown renewable raw materials, which do not compete with food sources. Furthermore, the energy required to produce these chemicals is low since the fermentation reaction is performed near ambient temperature. The chemicals are inherently safer than traditional chemicals because toxic solvents are not used, and the surfactants are biodegradable and do not contribute to increased greenhouse gas accumulation. Successful completion of the project will generate significant new scientific and technical information on new routes to making such surfactants.

这个小企业创新研究第一阶段项目旨在证明酰基甘氨酸表面活性剂可以通过一种新的细菌发酵途径生产。本项目的目的是构建一种生产甘氨酸酰基的菌株，并提供该表面活性剂的样品进行商业评价。一个成功的结果将证明酰基甘氨酸可以通过发酵生产。表面活性剂是清洁产品的气泡成分，使其具有清洁能力。目前，表面活性剂是由石油或棕榈油等种子油制成的。这些原材料的使用增加了温室气体污染，也导致了热带雨林的砍伐。零售商要求更环保的产品，监管机构要求新的毒性最低的化学品。对绿色化学品的需求为用更环保的替代品取代现有的表面活性剂创造了机会。拟议创新的更广泛/商业影响将是酰基甘氨酸表面活性剂的商业化。对社会的其他好处是，使用这种技术生产的化学品将使用国内种植的可再生原材料生产，而不会与食物来源竞争。此外，由于发酵反应是在接近环境温度的情况下进行的，因此生产这些化学物质所需的能量很低。由于不使用有毒溶剂，而且表面活性剂是可生物降解的，不会增加温室气体的积累，这些化学物质本身就比传统化学物质更安全。该项目的成功完成将为制造此类表面活性剂的新路线提供重要的新科学和技术信息。