Z-Project: Coordination and Administration, Sampling, Assessment, Data Integration and Analysis

Z项目将确保本建议书中隐含的主要服务功能。该项目将处理行政问题，例如，总体上包括资金的财务管理、工作组的协调以及资源分配、流动和时限。它将确保受试者、患者和对照组的采样和招募一致，避免系统选择。它将在所有工作包中对结构和领域提供全面、标准化和尽可能一致/相同的临床、诊断和表型评估，包括全面质量保证和在整个项目中建立电子数据库。最后，Z-项目将建议和协调统计分析和跨中心的数据建模，为单个项目任务之外的综合分析（潜在结构）和相互之间特定工作包的协调/整合做准备。单个项目相互关联，相互依赖。因此，Z项目的协调和集成任务是贯穿整个项目的连续任务。该项目将有助于对各组项目进行综合分析，以回答本提案的主要研究问题。

The Z project will ensure main service functions implied in this proposal. The project will take care of administrative issues e.g. overall including financial administration of funds, coordination of work groups and allocation of resources, flow and time lines. It will ensure consistent sampling and recruitment of subjects, patients and controls, avoiding systematic selection. It will provide a comprehensive, standardized and as far as possible coherent/identical clinical, diagnostic and phenotypic assessment of constructs and domains across all work packages, including overall quality assurance and the establishment of an electronic data base throughout the project. Finally, the Z-project will advise and coordinate statistical analyses and modeling of data across centers in preparation for integrated analyses (latent constructs) beyond the single project tasks and coordination/ integration of the specific work packages amongst each other. The single projects are interrelated and critically dependent on each other. Thus, coordination and integration tasks of the Z-project are continuous tasks throughout the project. This project will help to conduct integrative analyses across groups of projects to answer the main research questions of this proposal.