Z-Project: Coordination and Administration, Sampling, Assessment, Data Integration and Analysis

Z项目将确保本提案中隐含的主要服务功能。该项目将处理行政问题，例如总体管理问题，包括资金的财务管理、工作组的协调和资源分配、流程和时间安排。它将确保对受试者、患者和对照进行一致的抽样和招募，避免系统地选择。它将对所有工作包的结构和领域提供全面、标准化和尽可能连贯/相同的临床、诊断和表型评估，包括全面质量保证和在整个项目中建立电子数据库。最后，Z项目将为跨中心的数据统计分析和建模提供建议和协调，为超越单一项目任务的综合分析(潜在结构)以及具体工作包之间的协调/整合做好准备。这些单独的项目相互关联，严重依赖于彼此。因此，Z-项目的协调和整合任务是贯穿整个项目的连续任务。该项目将有助于进行跨项目组的综合分析，以回答该提案的主要研究问题。

The Z project will ensure main service functions implied in this proposal. The project will take care of administrative issues e.g. overall including financial administration of funds, coordination of work groups and allocation of resources, flow and time lines. It will ensure consistent sampling and recruitment of subjects, patients and controls, avoiding systematic selection. It will provide a comprehensive, standardized and as far as possible coherent/identical clinical, diagnostic and phenotypic assessment of constructs and domains across all work packages, including overall quality assurance and the establishment of an electronic data base throughout the project. Finally, the Z-project will advise and coordinate statistical analyses and modeling of data across centers in preparation for integrated analyses (latent constructs) beyond the single project tasks and coordination/ integration of the specific work packages amongst each other. The single projects are interrelated and critically dependent on each other. Thus, coordination and integration tasks of the Z-project are continuous tasks throughout the project. This project will help to conduct integrative analyses across groups of projects to answer the main research questions of this proposal.