CAREER: SusChEM - Sustainable Palladium-Catalyzed C-C Bond-Forming Reactions

职业：SusChEM - 可持续的钯催化 C-C 键形成反应

• 批准号: 1254783
• 负责人: Silas Cook
• 金额: $ 57.5万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1254783&HistoricalAwards=false
• 关键词: CAREER; SusChEM; Sustainable; Palladium; Catalyzed

The Chemistry Synthesis program is supporting the research of Professor Silas Cook at Indiana University with this CAREER award. Professor Cook's laboratory works to design reaction manifolds that may lead to new approaches in carbon-carbon bond formation. By utilizing Csp3-carbopalladium intermediates generated from alkyl electrophiles in migratory insertion pathways, the general problem of beta-hydride elimination can be avoided. Once beta-hydride elimination is avoided, complexity building cascade reactions will be developed, which would streamline the synthesis of complex molecular architectures. Specifically, reactions based on the alkyne insertions into alkylpalladium bonds will be explored. This approach should eliminate the pre-functionalization required for standard palladium-mediated cross-coupling reactions, thereby reducing waste and improving the sustainability of these synthetic transformations. The successful development of this research program is expected to have positive impact on a wide range of endeavors requiring the preparation of synthetic organic compounds, including pharmaceutical, agrochemical, and materials industries, as well as biological and chemical research. The CAREER Award will also provide support for two education programs. The first program allows Indiana University undergraduate students to take their research experience back to their hometowns in rural Indiana to team-teach classes on catalysis with their former high school teachers. These undergraduate Ambassadors of Catalysis will use a hands-on demonstrations and discuss their ongoing research to recruit the next generation of scientists. The second program seeks to improve and expand the team's iOS 'Named Reactions' application for the iPhone, iPod, and iPad. This free educational software has the potential to reach budding scientists throughout the world.

化学综合计划正在为印第安纳大学的Silas Cook教授提供研究，并获得了该职业奖。 库克教授的实验室著作设计了反应歧管，这些反应歧管可能导致碳碳键形成的新方法。 通过利用迁移插入途径中烷基电力产生的CSP3-碳化石中间体，可以避免β-氢化物消除的一般问题。 一旦避免了β-氢化物消除，就会开发复杂性构建级联反应，这将简化复杂分子体系结构的合成。 具体而言，将探索基于炔基插入烷基丙基键的反应。 这种方法应消除标准钯介导的交叉偶联反应所需的预官能化，从而减少废物并改善这些合成转化的可持续性。 预计该研究计划的成功开发将对需要制备合成有机化合物的各种努力产生积极影响，包括药物，农业化学和材料行业以及生物学和化学研究。 职业奖还将为两个教育计划提供支持。第一个课程使印第安纳大学的本科生可以将研究经验带回印第安纳州农村地区的家乡，以与他们的前高中老师进行催化课程。 这些催化的本科大使将使用动手示范，并讨论他们正在进行的研究以招募下一代科学家。第二个程序旨在改善和扩展iPhone，iPod和iPad的团队iOS的iOS“命名Reactions”申请。 这种免费的教育软件有可能吸引全球崭露头角的科学家。