CAREER: SusChEM - Sustainable Palladium-Catalyzed C-C Bond-Forming Reactions

职业：SusChEM - 可持续的钯催化 C-C 键形成反应

• 批准号: 1254783
• 负责人: Silas Cook
• 金额: $ 57.5万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1254783&HistoricalAwards=false
• 关键词: CAREER; SusChEM; Sustainable; Palladium; Catalyzed

The Chemistry Synthesis program is supporting the research of Professor Silas Cook at Indiana University with this CAREER award. Professor Cook's laboratory works to design reaction manifolds that may lead to new approaches in carbon-carbon bond formation. By utilizing Csp3-carbopalladium intermediates generated from alkyl electrophiles in migratory insertion pathways, the general problem of beta-hydride elimination can be avoided. Once beta-hydride elimination is avoided, complexity building cascade reactions will be developed, which would streamline the synthesis of complex molecular architectures. Specifically, reactions based on the alkyne insertions into alkylpalladium bonds will be explored. This approach should eliminate the pre-functionalization required for standard palladium-mediated cross-coupling reactions, thereby reducing waste and improving the sustainability of these synthetic transformations. The successful development of this research program is expected to have positive impact on a wide range of endeavors requiring the preparation of synthetic organic compounds, including pharmaceutical, agrochemical, and materials industries, as well as biological and chemical research. The CAREER Award will also provide support for two education programs. The first program allows Indiana University undergraduate students to take their research experience back to their hometowns in rural Indiana to team-teach classes on catalysis with their former high school teachers. These undergraduate Ambassadors of Catalysis will use a hands-on demonstrations and discuss their ongoing research to recruit the next generation of scientists. The second program seeks to improve and expand the team's iOS 'Named Reactions' application for the iPhone, iPod, and iPad. This free educational software has the potential to reach budding scientists throughout the world.

化学合成项目为印第安纳大学塞拉斯·库克教授的研究提供了CAREER奖。库克教授的实验室致力于设计反应流形，这可能会导致碳-碳键形成的新方法。通过在迁移插入途径中利用烷基亲电试剂产生的csp3 -碳钯中间体，可以避免消除β -氢化物的普遍问题。一旦避免了-氢化物的消除，复杂的级联反应将被开发出来，这将简化复杂分子结构的合成。具体来说，基于炔插入到烷基钯键的反应将被探索。这种方法应该消除标准钯介导的交叉偶联反应所需的预功能化，从而减少浪费并提高这些合成转化的可持续性。这项研究计划的成功发展预计将对合成有机化合物的制备产生广泛的积极影响，包括制药、农化、材料工业以及生物和化学研究。CAREER奖还将为两个教育项目提供支持。第一个项目允许印第安纳大学的本科生将他们的研究经验带回印第安纳州农村的家乡，与他们以前的高中老师一起组队教授催化课程。这些大学生催化大使将通过动手演示和讨论他们正在进行的研究来招募下一代科学家。第二个项目旨在改进和扩展团队的iOS“Named Reactions”应用程序，适用于iPhone、iPod和iPad。这个免费的教育软件有潜力接触到世界各地崭露头角的科学家。