Postdoctoral Fellowship: New Directions in Epigenetics

博士后奖学金：表观遗传学的新方向

• 批准号: 1256651
• 负责人: Elizabeth Armstrong
• 金额: $ 7.5万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1256651&HistoricalAwards=false
• 关键词: Postdoctoral; Fellowship; New; Directions; Epigenetics

Beginning in the 1980s, Dr. David Barker theorized that conditions and exposures during early development may relate to epigenetic modifications that effect outcomes in later life. This view has permeated scientific literature and practice, precipitating a new field of basic science and capturing public attention. Drawing on in-depth interviews with scientists working in this area, fieldwork in basic science settings, and a content analysis of scientific literature and popular media coverage, this research examines this scientific development. As scientific debates and public conversations about genetics continue, a fuller understanding of the ascendant epigenetic paradigm will assist broader understandings of determinants of health and disease. With growing concern about the prevalence of chronic diseases, this emergent science engages pressing health concerns.

从 20 世纪 80 年代开始，David Barker 博士提出理论认为，早期发育过程中的条件和暴露可能与影响以后生活结果的表观遗传修饰有关。这种观点已经渗透到科学文献和实践中，催生了基础科学的新领域并引起了公众的关注。本研究通过对在该领域工作的科学家的深入访谈、基础科学环境中的实地考察以及对科学文献和大众媒体报道的内容分析，检验了这一科学发展。随着关于遗传学的科学辩论和公众对话的继续，对方兴未艾的表观遗传范式的更全面理解将有助于更广泛地理解健康和疾病的决定因素。随着人们对慢性病患病率的日益关注，这一新兴科学解决了紧迫的健康问题。