GOALI: DNA in Extreme Confinement

最近展示的拉伸DNA长片段用于基因组图谱的能力表明，需要更好地了解DNA在极端限制下的行为。这项计划的目标是为纳米通道中长DNA分子在极端受限条件下的平衡性质和动力学发展出一种“工程质量”的描述，并将预测结果与BNG及其技术产生的实验观测结果进行比较。该项目的成功可以通过提供对限制在纳米通道中的DNA的基本了解来帮助这一新的DNA图谱技术的发展。这也是一种优秀的学术和产业合作伙伴关系，可以帮助开发下一代DNA测序和测绘技术。

The recently demonstrated ability to stretch out long segments of DNA for genomic mapping points to a need to better understand the behavior of DNA in extreme confinement. This goal of this proposal is to develop an "engineering quality" description for the equilibrium properties and dynamics of long DNA molecules under extreme confinement in a nanochannel and to compare the predictions with experimental observations generated by BNG and its technology.The success of this project can help the development of this new DNA mapping technology by providing a fundamental understanding of DNA confined in nanochannels. This is also an excellent academic-industrial partnership that can help the development of next-generation DNA sequencing and mapping technologies.