GOALI: DNA in Extreme Confinement

目标：极度禁闭中的 DNA

• 批准号: 1262286
• 负责人: Kevin Dorfman
• 金额: $ 28.29万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1262286&HistoricalAwards=false
• 关键词: GOALI; DNA; Extreme; Confinement

The recently demonstrated ability to stretch out long segments of DNA for genomic mapping points to a need to better understand the behavior of DNA in extreme confinement. This goal of this proposal is to develop an "engineering quality" description for the equilibrium properties and dynamics of long DNA molecules under extreme confinement in a nanochannel and to compare the predictions with experimental observations generated by BNG and its technology.The success of this project can help the development of this new DNA mapping technology by providing a fundamental understanding of DNA confined in nanochannels. This is also an excellent academic-industrial partnership that can help the development of next-generation DNA sequencing and mapping technologies.

最近展示的拉伸长DNA片段用于基因组作图的能力指出需要更好地理解DNA在极端限制下的行为。这个项目的目标是开发一个“工程质量”的描述长DNA分子的平衡性质和动力学极端限制下的纳米通道，并比较预测与实验观察产生的BNG和它的technology.The成功的这个项目可以帮助这种新的DNA映射技术的发展，通过提供一个基本的理解限制在纳米通道中的DNA。这也是一个很好的学术-工业合作伙伴关系，可以帮助开发下一代DNA测序和绘图技术。