SEES Fellows: Recyclable Solid Supports as a Sustainable Platform Technology

SEES 研究员：可回收固体支撑物作为可持续平台技术

• 批准号: 1314022
• 负责人: Frank Leibfarth
• 金额: $ 50.54万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1314022&HistoricalAwards=false
• 关键词: SEES; Fellows; Recyclable; Solid; Supports

In this Award from the NSF Science, Engineering and Education for Sustainability Fellows (SEES Fellows Program) Dr. Frank Leibfarth from the Massachusetts Institute of Technology will develop recyclable solid supports for the efficient and economical production of complex molecules, including polysaccharides, peptides and oligonucleotides. This award has support from: the Directorate for Engineering; and the Division of Chemistry and the Division of Materials Science in the Directorate for Mathematical and Physical Sciences.The proposed work will combine solid phase synthesis on a polymer support with dynamic covalent chemistry with a continuous flow system to carry out the reactions that create the target molecules. The aim of studies like that proposed in this work is to develop better, more efficient methods for the synthesis of complex molecules (e.g. pharmaceuticals) with minimum production of chemical waste.Dr. Leibfarth will be working with collaborators Prof. Timothy F. Jamison of the Department of Chemistry at the Massachusetts Institute of and Dr. Sejal Patel of Novartis Institutes of Biomedical Research. Dr. Leibfarth will also work with the MIT Office of Engineering Outreach as well as the Society of Hispanic Professional Engineers on educational projects. This project is supported under the NSF Science, Engineering and Education for Sustainability Fellows (SEES Fellows) program, with the goal of helping to enable discoveries needed to inform actions that lead to environmental, energy and societal sustainability while creating the necessary workforce to address these challenges. With SEES Fellows support, this project will enable a promising early career researcher to establish themselves in an independent research career related to sustainability.

在NSF科学、工程和教育可持续发展研究员（SEES研究员计划）的这一奖项中，来自马萨诸塞州理工学院的Frank Leibfarth博士将开发可回收的固体支持物，用于有效和经济地生产复杂分子，包括多糖、肽和寡核苷酸。 该奖项得到了以下机构的支持：工程局;和数学和物理科学局的化学部和材料科学部。拟议的工作将结合联合收割机固相合成的聚合物支持与动态共价化学与连续流动系统进行反应，创造目标分子。Leibfarth博士将与合作者Timothy F教授合作，研究化学废物的最小化，以开发更好、更有效的合成复杂分子（如药物）的方法。马萨诸塞州生物医学研究所化学系的Jamison和诺华生物医学研究所的Sejal Patel博士。 Leibfarth博士还将与麻省理工学院工程推广办公室以及西班牙裔专业工程师协会合作开展教育项目。该项目得到了NSF科学，工程和教育可持续发展研究员（SEES研究员）计划的支持，其目标是帮助实现所需的发现，为导致环境，能源和社会可持续性的行动提供信息，同时创造必要的劳动力来应对这些挑战。在SEES研究员的支持下，该项目将使一个有前途的早期职业研究人员能够在与可持续发展相关的独立研究生涯中建立自己的地位。