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Regulation of Focal Adhesion Initiation by Lipids and Membrane Bending

Regulation of Focal Adhesion Initiation by Lipids and Membrane Bending
脂质和膜弯曲对局部粘附引发的调节
批准号:
1334847
负责人:
Peter Butler
金额:
$36.5万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-01 至 2017-08-31

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中文摘要
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英文摘要
The research objective of this award is to understand the very early parts of how cells adhere to surfaces such as natural extracellular matrices and artificial surfaces used in biomaterials. Specifically, this research will investigate how the membrane controls the transport of lipids and the recruitment of important adhesion molecules to adhesion plaques. These experiments will use advanced microscopes capable of measuring dynamics of cellular adhesions and molecular dynamics in these structures. If successful, these measurements would lead to a better understanding of cellular adhesion dynamics and why atherosclerotic lesions form in areas of low and oscillating fluid shear stress such as at blood vessel bifurcations and near stents. It may also be important for shear-induced vasodilation, which is known to counteract pressure-induced myogenic constriction in small arteries and thus is an important component of blood pressure control and hypertension. If successful, these studies would add significantly to the field's understanding of mechanosensing in particular and molecular scale functional organization of plasma membranes in general. This understanding may assist in future testing of mechanosensation theories and in the development of new biomechanical mimetics, such as unilamellar vesicles with proteins, proteoglycans, and cytoskeleton. Since almost all cells need to sense and apply force, these studies may have broad implications for many mechanobiological processes including bone remodeling, stem cell differentiation, and developmental biology. The proposed research on membrane mechanobiology will be integrated into graduate training and in undergraduate honors thesis preparation. This training will form the basis of outreach to young scientists (grades 6-12) in which molecular scale mechanobiology is made more accessible through modern 3-D visualization. Such outreach will provide opportunities to reach underrepresented groups such as women and minorities and students in rural Pennsylvania, who visit Penn State frequently as they consider their higher education options.
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Sustainable Summer Bridges from Campus to Campus: Retention Models for Transitioning Underrepresented Engineering Students
Consolidated nuclear physics grant 2011
  • 批准号:
    ST/J000094/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $277.34万
  • 财政年份:
    2011
  • 负责人:
    Peter Butler
  • 依托单位:
Nuclear Physics Rolling Grant
  • 批准号:
    ST/F012039/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $409.63万
  • 财政年份:
    2008
  • 负责人:
    Peter Butler
  • 依托单位:
Precision Tests of the Nuclear Wavefunction using Exotic Beams: Measurements of shape co-existence in 182,184Hg using Coulomb excitation
  • 批准号:
    PP/F000898/1
  • 项目类别:
    Research Grant
  • 资助金额:
    $22.19万
  • 财政年份:
    2007
  • 负责人:
    Peter Butler
  • 依托单位:
国内基金
海外基金
CAV2/CAV1通过调节Focal adhesion信号通路抑制鼻咽癌放疗抵抗的机制研究
  • 批准号:
    JCZRLH202500859
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
  • 依托单位: