SBIR Phase I: A green enzyme-based oxidative platform for fine chemical synthesis and remediation applications

SBIR 第一期：用于精细化学品合成和修复应用的绿色酶氧化平台

• 批准号: 1345963
• 负责人: Stephane Corgie
• 金额: $ 15万
• 依托单位: ZYMtronix Catalytic Systems Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1345963&HistoricalAwards=false
• 关键词: SBIR; Phase; green; enzyme; based

This Small Business Innovation Research Phase I project aims to increase the effectiveness of oxidative enzymes of high potential in chemical synthesis and chemical remediation applications. Enzyme-based systems, the greenest and most energy efficient processes known to-date, are replacing chemical-based systems due to their superior potential for energy savings and environmental benefits. While at the forefront of the green chemistry revolution, however, enzyme-based systems are difficult to come by. Their adoption has not been as fast, as widespread, or as beneficial as it otherwise could be because oxidative enzymes are not cost effective enough to replace chemicals. This project is developing an integrated technology for oxidative enzymes for industrial use. The project objectives consist of (1) manufacturing continuous flow reactors dedicated to processing ZYMtronix?s catalysts, (2) developing a synthesis process for key pharmaceutical precursors used in cancer treatment, and (3) demonstrating the remediation application for industrial contaminants. The anticipated technical results will benchmark reactor characteristics and the catalytic metrics of the aforementioned processes.The broader commercial potential of this project is to facilitate the adoption of oxidative enzymes in synthesis and remediation applications because they can replace precious metal catalysts, toxic solvents, and energy intensive processes. Additional benefits translate to safer processes and products for manufacturers, consumers and the environment. ZYMtronix patent-pending technology is estimated to be substantially more efficient and cost effective to operate when compared with chemical systems, increasing enzyme activity, decreasing enzyme inhibition, and expanding the enzyme´s range of operable conditions. Combined with proprietary reactors being developed, the catalysts can be recycled for continuous use. ZYMtronix´s technology serves the fine chemicals, pharmaceutical, as well as the water remediation, markets applicable to oxidative enzyme processes.

这个小企业创新研究第一阶段项目的目的是提高高潜力的氧化酶在化学合成和化学修复应用的有效性。 基于酶的系统是迄今为止已知的最绿色和最节能的工艺，由于其在节能和环境效益方面的上级潜力，正在取代基于化学的系统。然而，虽然处于绿色化学革命的前沿，但基于酶的系统很难获得。它们的采用并不像其他方法那样迅速，广泛或有益，因为氧化酶不具有足够的成本效益来取代化学品。该项目正在开发用于工业用途的氧化酶的综合技术。该项目的目标包括（1）制造连续流反应器专用于处理ZYMtronix？的催化剂，（2）开发用于癌症治疗的关键药物前体的合成工艺，以及（3）展示工业污染物的修复应用。预期的技术成果将基准反应器的特性和催化指标的上述processs.The更广泛的商业潜力，该项目是促进采用氧化酶的合成和补救应用，因为它们可以取代贵金属催化剂，有毒溶剂，和能源密集型的过程。 额外的好处可以转化为制造商、消费者和环境更安全的工艺和产品。据估计，与化学系统相比，ZYMtronix正在申请专利的技术在操作上效率更高，成本更低，增加了酶的活性，降低了酶的抑制作用，并扩大了酶的可操作条件范围。结合正在开发的专有反应器，催化剂可以回收以连续使用。ZYMtronix的技术服务于精细化学品、制药以及适用于氧化酶工艺的水修复市场。