I-Corps: Natural Polymer Based Systems for Bone Repair and Regeneration

I-Corps：基于天然聚合物的骨骼修复和再生系统

• 批准号: 1355327
• 负责人: Sangamesh Kumbar
• 金额: $ 5万
• 依托单位: University of Connecticut Health Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1355327&HistoricalAwards=false
• 关键词: Corps; Natural; Polymer; Based; Systems

This project will build upon prior research to improve upon a natural polymer-based scaffold technology for implant applications. Researchers have developed a mechanically competent bioactive biodegradable fixation device using cellulose, which is a polymer of natural origin. This polymer class has a long medical history as dialysis membrane, wound care system and pharmaceutical excipient. The research team previously evaluated cellulose-based scaffold systems for bone regeneration applications and has determined the biocompatibility, mechanical competence and osteoenic properties of cellulose scaffold system applications. Traditional metallic fixation devices such as plates and screws have several limitations and eventually may require additional surgery for removal. The biodegradable fixation devices developed through this project are designed to degrade completely, eliminating the need for a removal operation. This material platform is potentially stronger, more biocompatible and may meet the versatile needs in biological science and biomedical engineering. These products may also find applications to deliver bioactive molecules, antibiotics and pain medications to treat various aliments within the musculoskeletal system.

该项目将建立在先前的研究基础上，以改进用于植入物应用的天然聚合物支架技术。研究人员利用天然聚合物纤维素开发了一种具有机械活性的可生物降解固定装置。这类聚合物作为透析膜、伤口护理系统和药物赋形剂有着悠久的医学历史。研究小组先前评估了基于纤维素的支架系统用于骨再生的应用，并确定了纤维素支架系统应用的生物相容性、机械性能和成骨性能。传统的金属固定装置，如钢板和螺钉有一些局限性，最终需要额外的手术切除。通过该项目开发的可生物降解固定装置被设计为完全降解，无需去除手术。这种材料平台具有潜在的更强、更强的生物相容性，可以满足生物科学和生物医学工程的多种需求。这些产品还可以用于输送生物活性分子、抗生素和止痛药，以治疗肌肉骨骼系统内的各种营养。