Thermochemistry of Metal-Ligand Bonds (Singly and Multiply Charged) and Protonated Peptides

金属-配体键（单电荷和多电荷）和质子化肽的热化学

• 批准号: 1359769
• 负责人: Peter Armentrout
• 金额: $ 70.03万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1359769&HistoricalAwards=false
• 关键词: Thermochemistry; Metal; Ligand; Bonds; Singly

In this award, funded by the Chemical Structure, Dynamics and Mechanisms A (CSDM-A) Program of the Division of Chemistry Professor Peter Armentrout of the Department of Chemistry of the University of Utah and graduate student researchers are studying the reactivity of electrically-charged species (ions) with neutral molecules in extraordinarily well-defined systems. From these experiments, they obtain information about the energetics of reactions (thermochemistry) as well as information about the speed with which these reactions take place (kinetics). Students educated in the Armentrout laboratory will be trained for a wide variety of technical careers. Besides his scientific work, Prof. Armentrout reaches large numbers of members of the public through his Christmas Faraday Lectures at the University of Utah.Prof. Armentrout and his graduate students will be carrying out a series of experiments, exploring the reactivity of transition metal cations with neutral reaction partners, using the Armentrout group's guided ion beam mass spectrometer (GIBMS) instruments. Studies will include: (1) state-specific measurements of transition metal cation reactivity, with an emphasis on quantitative evaluation of spin-orbit effects on chemical reactivity; (2) measurement of solvation energies of multiply charged metal ions, including explicit quantification of the potential energy surface for charge separation channels, emphasizing environmentally and biologically important examples; (3) continued studies of binding of biologically-relevant molecules to metal cations and protonated systems; and (4) theoretical work to complement all of the experimental studies in (1) - (3). Students receiving training in Prof. Armentrout's laboratory have gone on to positions in academia and industry.

在该奖项中，由化学部化学结构，动力学和机制A（CSDM-A）计划资助，犹他州大学化学系的Peter Armentrout教授和研究生研究人员正在研究带电物质（离子）与中性分子在非常明确的系统中的反应性。 从这些实验中，他们获得有关反应能量学（热化学）以及这些反应发生速度（动力学）的信息。在Armentrout实验室接受教育的学生将接受各种技术职业的培训。 Armentrout教授除了科学工作外，还在犹他州大学举办了一系列的法拉第讲座，吸引了众多的公众人士。Armentrout教授和他的研究生将进行一系列的实验，利用Armentrout集团的制导离子束质谱仪（GIBMS）仪器，探索过渡金属阳离子与中性反应伙伴的反应性。 研究将包括：（1）过渡金属阳离子反应性的状态特异性测量，重点是对化学反应性的自旋-轨道效应的定量评估;（2）多电荷金属离子的溶剂化能的测量，包括电荷分离通道的势能面的明确量化，强调环境和生物学上重要的例子;（3）继续研究生物相关分子与金属阳离子和质子化系统的结合;（4）理论工作，以补充（1）-（3）中的所有实验研究。 在Armentrout教授的实验室接受培训的学生已经在学术界和工业界任职。