DISSERTATION RESEARCH: Elucidating the genomic signature of mate competition in a pipefish using a population genomics approach

论文研究：利用群体基因组学方法阐明海龙交配竞争的基因组特征

• 批准号: 1401688
• 负责人: Adam Jones
• 金额: $ 1.89万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1401688&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Elucidating; genomic; signature

This study aims to understand how adult behavior can determine which genes are passed from parents to offspring and how these processes vary among populations within a species. These goals will be addressed by comparing the natural genetic variation in adults and their offspring within a single population of pipefish. This study will also quantify genetic variation in multiple populations across a broad geographic range, which will provide data regarding how reproductive patterns vary among populations. The focal organism is the straight-nosed pipefish, Nerophis ophidion, which is found in Sweden, and the project takes advantage of recent advances in DNA sequencing technology to analyze the genetic variation at the scale of the entire genome. This species is of interest because females compete intensely for access to mates and the males provide all care for the developing offspring. This project addresses a major subject in biology and genetics, namely how behaviors at different stages during the life cycle affect how genes are passed on from one generation to the next. Additionally, the analytical approach of comparing genetic variation between adults and offspring using new sequencing technologies is a novel combination of a mathematical model from the 1970's and new statistical methods. This approach could have broad applications in many fields and for many species, including as a diagnostic tool for understanding what pressures are affecting threatened and endangered species and for understanding multi-generational effects of human diseases.

这项研究旨在了解成年人的行为如何决定哪些基因从父母传给后代，以及这些过程如何在物种内的不同种群中变化。这些目标将通过比较单一种群中成鱼及其后代的自然遗传变异来实现。这项研究还将量化广泛地理范围内多个种群的遗传变异，这将提供有关种群之间生殖模式如何变化的数据。重点生物是在瑞典发现的直鼻笛鱼，该项目利用DNA测序技术的最新进展，在整个基因组的规模上分析遗传变异。这一物种之所以令人感兴趣，是因为雌性为获得配偶而激烈竞争，而雄性则为发育中的后代提供所有的照顾。这个项目解决了生物学和遗传学中的一个主要主题，即生命周期不同阶段的行为如何影响基因如何从一代传到下一代。此外，使用新的测序技术比较成年和后代之间的遗传变异的分析方法是20世纪70年代S的数学模型和新的统计方法的新组合。这一方法可在许多领域和许多物种中得到广泛应用，包括作为一种诊断工具，用于了解哪些压力正在影响受威胁和濒危物种，以及了解人类疾病的多代影响。