I-Corps: From Compacts to Integrated Systems: A New Paradigm for the Design and Manufacture of Pharmaceuticals

拟议的团队为药物剂型的设计和制造引入了新的范式。新的平台技术，3D集成制药（3D IP），灵感来自3D IC（3D集成电路）模型实现的令人印象深刻的进步。所提出的方法，新颖的制药行业的基本概念，包括在看医药产品作为集成系统。使用3D IP，剂型是根据预先制定的蓝图，而不是通过混合和压缩粉末，从预制的工作组件组装而成。其结果是一种相对简单的方法，可以制造具有定制形状、物理尺寸以及最重要的药物释放曲线的药物产品。3D IP是一种新型平台，专注于生产药物口服剂型。 类似于通过多个功能组件的3D层堆叠构建的3D集成电路的设计，3D IP剂型通过堆叠预制的功能组件（例如活性成分载体、增溶功能、ID/防伪和防篡改）来组装。3D IP技术可应用于需要目标或活性化合物的可定制释放的领域，这些领域超出了口服药物，进入透皮市场，智能贴片，农用化学品，营养保健品和个人护理产品。

The proposed team introduces a new paradigm for the design and manufacture of pharmaceutical dosage forms. The new platform technology, 3D Integrated Pharmaceuticals (3D IP), is inspired after the impressive progress realized by the 3D IC (3D Integrated Circuits) model. The underlying concept of the proposed approach, novel to the pharmaceutical industry, consists in looking at pharmaceutical products as integrated systems. With 3D IP, dosage forms are assembled from pre-fabricated working components, according to a pre-established blueprint instead of by blending and compressing powders. The result is a comparatively simple means of making pharmaceutical products with customized shape, physical dimensions, and most importantly, drug release profile. 3D IP is a novel platform that has focused on producing pharmaceutical oral dosage forms. Analogous to the design of 3D integrated circuits, built by the 3D layer stacking of multiple functional components, 3D IP dosage forms are assembled by stacking pre-fabricated functional components such as active ingredient carrier, solubilizing function, ID/anti-counterfeiting, and tamper prevention. The 3D IP technology has applications in areas where customizable release for a target or active compound is needed, which extend beyond oral pharmaceuticals, into transdermal markets, smart patches, agrochemicals, nutraceuticals and personal care products.