The unifying principles of biomolecular interactions as a predictive framework for biological mechanisms

在这个研究项目中，PI将发展统一的物理原理来研究复杂的生物系统。这些进展将为将单分子理论扩展到体内的分子行为奠定基础。该计划将培训初级科学家开发基于物理学的概念方法，这些方法可以涵盖生命系统的复杂性，并成为这一多学科领域的领导者。在她在加州大学圣迭戈分校成功开发生物物理课程的基础上，PI将扩大她的努力，将生物物理融入到她所在部门以外的课程中。国际和平协会将继续并扩大她的外展活动，努力鼓励和培训来自不同学术和社会背景的科学家。该项目的研究和培训活动将使生物技术行业受益。该项目的目标是建立统一的物理原理，管理复杂生物分子的功能动力学。该项目将提供一个理论框架，可以预测生物学机制作为既定统一原则的表现。来自非平衡统计物理的方法将被开发并应用于制定理论方法，这些方法足够普遍，适用于广泛的生物分子系统和实验技术，但又足够简单，以产生分析理论和产生可实验验证的预测。这一研究计划将把PI小组开发并被证明成功用于小生物分子的方法学扩展到更复杂、大规模的多分子组装及其功能行为中涉及的构象变化。

In this research project, the PI will develop unifying physical principles to study complex biological systems. These developments will build a foundation for extending single-molecule theory to molecular behavior in vivo. This program will train junior scientists to develop physics-based conceptual approaches that can encompass the complexity of living systems and to become leaders in this multi-disciplinary field. Building upon her successful development of the biological physics curriculum at UCSD, the PI will expand her efforts to integrate biological physics into curriculums beyond her home department. The PI will continue and expand upon her outreach initiatives in an effort to encourage and train scientists from a diverse range of academic and social backgrounds. The research and training activities in this project will benefit biotechnology industry.The goal of this project is to establish the unifying physical principles that govern the functional dynamics of complex biomolecules. The project will provide a theoretical framework that can predict biological mechanisms as manifestations of the established unifying principles. Methods from nonequilibrium statistical physics will be developed and applied to formulate theoretical approaches that are sufficiently general to be applicable to a broad range of biomolecular systems and experimental techniques, and yet sufficiently simple to result in an analytical theory and generate experimentally testable predictions. This research program will extend the methodologies, developed in the PI's group and proven successful for small biomolecules, to more complex, large-scale multi-molecular assemblies and the conformational changes involved in their functional behavior.