The unifying principles of biomolecular interactions as a predictive framework for biological mechanisms

在这个研究项目中，PI将开发统一的物理原理来研究复杂的生物系统。这些进展将为将单分子理论扩展到体内分子行为奠定基础。该计划将培养初级科学家开发基于物理的概念方法，可以涵盖生命系统的复杂性，并成为这个多学科领域的领导者。在UCSD生物物理课程成功开发的基础上，PI将扩大她的努力，将生物物理学融入她的家庭部门之外的课程。PI将继续并扩大其外联活动，以鼓励和培训来自不同学术和社会背景的科学家。本项目的研究和培训活动将使生物技术产业受益。本项目的目标是建立管理复杂生物分子功能动力学的统一物理原理。该项目将提供一个理论框架，可以预测生物机制作为既定统一原则的表现。从非平衡统计物理学的方法将被开发和应用，以制定理论的方法，是足够普遍的，适用于广泛的生物分子系统和实验技术，但足够简单的结果在一个分析理论，并产生实验可检验的预测。该研究计划将扩展PI小组开发的方法，并证明对小生物分子是成功的，以更复杂，大规模的多分子组装及其功能行为中涉及的构象变化。

In this research project, the PI will develop unifying physical principles to study complex biological systems. These developments will build a foundation for extending single-molecule theory to molecular behavior in vivo. This program will train junior scientists to develop physics-based conceptual approaches that can encompass the complexity of living systems and to become leaders in this multi-disciplinary field. Building upon her successful development of the biological physics curriculum at UCSD, the PI will expand her efforts to integrate biological physics into curriculums beyond her home department. The PI will continue and expand upon her outreach initiatives in an effort to encourage and train scientists from a diverse range of academic and social backgrounds. The research and training activities in this project will benefit biotechnology industry.The goal of this project is to establish the unifying physical principles that govern the functional dynamics of complex biomolecules. The project will provide a theoretical framework that can predict biological mechanisms as manifestations of the established unifying principles. Methods from nonequilibrium statistical physics will be developed and applied to formulate theoretical approaches that are sufficiently general to be applicable to a broad range of biomolecular systems and experimental techniques, and yet sufficiently simple to result in an analytical theory and generate experimentally testable predictions. This research program will extend the methodologies, developed in the PI's group and proven successful for small biomolecules, to more complex, large-scale multi-molecular assemblies and the conformational changes involved in their functional behavior.