The unifying principles of biomolecular interactions as a predictive framework for biological mechanisms

生物分子相互作用的统一原理作为生物机制的预测框架

• 批准号: 1411884
• 负责人: Olga Dudko
• 金额: $ 90.41万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1411884&HistoricalAwards=false
• 关键词: unifying; principles; biomolecular; interactions; predictive

In this research project, the PI will develop unifying physical principles to study complex biological systems. These developments will build a foundation for extending single-molecule theory to molecular behavior in vivo. This program will train junior scientists to develop physics-based conceptual approaches that can encompass the complexity of living systems and to become leaders in this multi-disciplinary field. Building upon her successful development of the biological physics curriculum at UCSD, the PI will expand her efforts to integrate biological physics into curriculums beyond her home department. The PI will continue and expand upon her outreach initiatives in an effort to encourage and train scientists from a diverse range of academic and social backgrounds. The research and training activities in this project will benefit biotechnology industry.The goal of this project is to establish the unifying physical principles that govern the functional dynamics of complex biomolecules. The project will provide a theoretical framework that can predict biological mechanisms as manifestations of the established unifying principles. Methods from nonequilibrium statistical physics will be developed and applied to formulate theoretical approaches that are sufficiently general to be applicable to a broad range of biomolecular systems and experimental techniques, and yet sufficiently simple to result in an analytical theory and generate experimentally testable predictions. This research program will extend the methodologies, developed in the PI's group and proven successful for small biomolecules, to more complex, large-scale multi-molecular assemblies and the conformational changes involved in their functional behavior.

在该研究项目中，PI将开发统一的物理原理来研究复杂的生物系统。这些发展将为将单分子理论扩展到体内的分子行为，为将单分子理论扩展为基础。该计划将训练初级科学家开发基于物理的概念方法，这些方法可以涵盖生活系统的复杂性并成为这个多学科领域的领导者。在加州大学UCSD的生物物理学课程的成功开发的基础上，PI将扩大将生物物理学纳入家庭部门以外的课程的努力。 PI将继续并扩大她的外展计划，以鼓励和培训来自各种学术和社会背景的科学家。该项目中的研究和培训活动将使生物技术行业受益。该项目的目的是建立统一的身体原理来控制复杂生物分子的功能动态。该项目将提供一个理论框架，可以将生物学机制预测为已建立的统一原则的表现。将开发和应用非平衡统计物理学的方法来制定足够一般的理论方法，这些方法足以适用于广泛的生物分子系统和实验技术，但足够简单，可以实现分析理论并产生实验性测试的预测。该研究计划将将PI组中开发的方法扩展到对小生物分子的成功，并将其成功地扩展到更复杂，大规模的多分子组件以及其功能行为所涉及的构象变化。