CC*IIE Networking Infrastructure: Data Driven Expansion at The University of South Alabama

该项目的目的是扩大南阿拉巴马大学的网络基础设施，以提高米切尔癌症研究所和计算机学院科学家之间的合作研究能力。基础设施的改进对于处理大型数据库和图像数据所需的大量数据传输是必要的，这些数据构成了本研究的核心。这些校园网络改进所带来的研究包括调查描述性数据驱动的分析方法在多大程度上可以发现用户定义的肿瘤分组中癌症突变组之间的关系。由于癌症的传统特征通常出现在各种形式的癌症中，因此表面上不相关的基因之间的突变相互作用必须存在，并且必须在微调肿瘤对其环境的行为方面发挥作用。通过采用数据驱动的方法，将每个肿瘤基因组视为一个独立的进化实验，除了传统的关注驱动突变之外，还可以评估主要由乘客突变组成的独特突变特征。该项目将基础数据网络容量提高了10倍，并通过将校园核心网络转换为高性能10Gbps网络，为南阿拉巴马大学的研究和教育带来了好处。

The project's purpose is to expand the University of South Alabama Cyberinfrastructure to improve collaborative research capability between scientists in the Mitchell Cancer Institute and the School of Computing. Infrastructure improvements are necessary to handle the high volume data transfer required for large databases and imagery data that form the core of this research.Research enabled by these campus network improvements includes investigations into the degree to which descriptive data driven analysis methods can discover relationships among groups of cancer mutations across user-defined tumor groupings. Because the traditional hallmarks of cancer commonly arise in diverse forms of cancer, mutational interplay between seemingly unrelated genes must exist and must play a role in fine tuning tumor behavior to its environment. By employing a data driven approach, where each tumor genome is viewed as an independent evolution experiment, it is possible to evaluate the unique mutational signatures composed predominately of passenger mutations, in addition to the traditional focus on driver mutations. This project increases underlying data networking capacity by a factor of 10, and results in benefits to research and education across the University of South Alabama by transforming the campus core network to a high performance 10Gbps network.