RCN: A Network to Promote Comparative Genome to Phenome Analysis

RCN：促进比较基因组与表型组分析的网络

• 批准号: 1456942
• 负责人: Carl Schmidt
• 金额: $ 50万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1456942&HistoricalAwards=false
• 关键词: RCN; Network; Promote; Comparative; Genome

Understanding the relationship between an organism's DNA (the genome) and the set of phenotypic characteristics that result from genomic expression (the phenome) is a central challenge in biology. High throughput sequencing and phenotypic data from multiple species provides an opportunity for comparative analysis of genome to phenome data. The objective of this award is to develop a Genome to Phenome Network (G2PN) Research Collaboration Network (RCN) aimed at promoting comparative analysis of vertebrate and invertebrate animals to enrich our understanding of the relationship between genomes and phenomes. The G2PN will bring together groups using diverse experimental approaches to understand how the genome ultimately manifests the phenome. The G2PN will provide tools necessary for scientists to exploit comparative genomics approaches to understand genome to phenome relationships. In addition, the activities of the G2PN will provide training for undergraduates, graduate students and post-doctoral fellows in the science of comparative biology and genome to phenome relationships. Participation of researchers from universities and colleges serving historically underrepresented groups will be particularly encouraged. The G2PN will also generate educational modules to further enhance student training in G2P concepts. All of the resources developed by the G2PN will be freely available to the scientific community, communicated at scientific meetings, and published in peer-reviewed journals.A major objective of the G2PN will be to encourage researchers to leave their silos and develop collaborative teams that will exploit comparative approaches to enhance our understanding of genome to phenome relationships. The G2PN RCN goals include: Establishing an international G2PN with scientists studying a diverse range of animals; G2PN activities that will directly foster the development of comparative studies by promoting standardization of experimental approaches, data and metadata collection and bioinformatic analyses; promoting new collaborations and proposals among scientists from different specialties through international meetings, web sites, publications and social media; and promoting understanding of comparative genomic studies through the development of training modules using diverse educational modalities. Ultimately, this RCN will improve our understanding of the relationships between selective pressures, genomic changes and phenotypic outcomes. The standards developed by this RCN will find applicability far beyond the science directly affected by the G2P network. These standards will facilitate laboratory work and data comparability across a broad range of species and studies.

了解生物体的DNA（基因组）和由基因组表达产生的一系列表型特征（表型组）之间的关系是生物学的一个核心挑战。 来自多个物种的高通量测序和表型数据为基因组与表型组数据的比较分析提供了机会。该奖项的目的是建立一个基因组表型网络（G2 PN）研究合作网络（RCN），旨在促进脊椎动物和无脊椎动物的比较分析，以丰富我们对基因组和表型之间关系的理解。G2 PN将汇集使用不同实验方法的小组，以了解基因组最终如何表现出表型。 G2 PN将为科学家提供必要的工具，以利用比较基因组学方法来了解基因组与表型组的关系。此外，G2 PN的活动将为本科生、研究生和博士后研究员提供比较生物学和基因组与表型组关系科学方面的培训。将特别鼓励为历来代表性不足的群体服务的大学和学院的研究人员参加。 G2 PN还将生成教育模块，以进一步加强学生对G2 P概念的培训。G2 PN开发的所有资源将免费提供给科学界，在科学会议上交流，并在同行评审的期刊上发表。G2 PN的一个主要目标是鼓励研究人员离开他们的孤岛，发展合作团队，利用比较方法来增强我们对基因组与表型组关系的理解。G2 PN RCN的目标包括：与研究各种动物的科学家建立一个国际G2 PN; G2 PN活动将通过促进实验方法、数据和元数据收集以及生物信息学分析的标准化，直接促进比较研究的发展;通过国际会议、网站、出版物和社交媒体，促进不同专业科学家之间的新合作和建议;以及通过使用不同的教育模式开发培训模块，促进对比较基因组研究的理解。最终，这个RCN将提高我们对选择压力，基因组变化和表型结果之间关系的理解。 该RCN开发的标准将发现其适用性远远超出G2 P网络直接影响的科学。这些标准将促进实验室工作和广泛物种和研究的数据可比性。