Nanoparticle reinforced bioactive polysaccharide hybrid composites for medical applications (Nanobiocomp)

用于医疗应用的纳米颗粒增强生物活性多糖杂化复合材料（Nanobiocomp）

• 批准号: 21909622
• 负责人: Professor Dr.-Ing. Peter Greil
• 金额: --
• 依托单位: Department of Materials Science
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/21909622?language=en
• 关键词: Nanoparticle; reinforced; bioactive; polysaccharide; hybrid

Nanoparticle reinforcement of polysaccharides may provide a versatile tool to design and manufacture a novel generation of bioactive implant and artifical tissue matrix materials where an excellent biomechanical stability might be combined with high elasticity of flexible fibrous scaffold structures. The proposed project involves two major issues: i.) dispersion of the nanosized bioactive ceramic powder (TiCh and Cas(PO4)3/OH) in regenerated polysaccharide matrix and fabrication of bioactive textile and multilayer gradient structures ii.) characterization of mechanical behavior and biofunctional efficency. Processing of powder/ polysaccharide hybrid composites and fabrication of scaffold structures will be dealt with at Erlangen University. At Sung Kwon Kwan University the nanoparticle reinforced hybrid material composites and structures will be analysed for the mechanical and biological behavior in cooperation with the medical school.

纳米颗粒增强多糖可以为设计和制造新一代生物活性植入物和人工组织基质材料提供一个通用的工具，其中优异的生物力学稳定性可能与柔性纤维支架结构的高弹性相结合。该项目涉及两个主要问题：1)纳米级生物活性陶瓷粉末（TiCh和Cas(PO4)3/OH）在再生多糖基质中的分散和生物活性纺织品和多层梯度结构的制备；2)力学行为和生物功能效率的表征。粉末/多糖混合复合材料的加工和支架结构的制造将在埃尔兰根大学进行。在成权馆大学，将与医学院合作，对纳米颗粒增强混合材料复合材料和结构进行力学和生物行为分析。