Research Initiation Award: High-resolution electronic spectroscopy of inter/intra-molecular interactions on biologically relevant molecules

研究启动奖：生物相关分子的分子间/分子内相互作用的高分辨率电子光谱

• 批准号: 1505311
• 负责人: John Yi
• 金额: $ 19.99万
• 依托单位: Winston-Salem State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1505311&HistoricalAwards=false
• 关键词: Research; Initiation; Award; resolution; electronic

The Historically Black Colleges and Universities-Undergraduate Program (HBCU-UP) Research Initiation Awards (RIAs) provide support to STEM junior faculty at HBCUs who are starting to build a research program, as well as for mid-career faculty who may have returned to the faculty ranks after holding an administrative post or who needs to redirect and rebuild a research program. Faculty members may pursue research at their home institution, at an NSF-funded Center, at a research intensive institution or at a national laboratory. The RIA projects are expected to help further the faculty member's research capability and effectiveness, to improve research and teaching at his or her home institution, and to involve undergraduate students in research experiences. With support from the National Science Foundation, Winston-Salem State University (WSSU) will conduct research on the structures of biomolecules which are key to understanding processes in biological systems. The research is a collaborative project with the National Institute of Standards and Technology (NIST). This project will enhance WSSU's research capabilities and the educational experiences of undergraduates. Students will receive mentoring, training and research experiences at WSSU and NIST. The research and educational efforts are expected to expand the participation of groups underrepresented in STEM and support WSSU's vision and mission of strengthening and broadening the participation of underrepresented groups. This goals of the research are to: 1) Explore the direct connection between geometry and chemical reaction dynamics by studying the conformational preferences for photon induced intramolecular formation in Tryptophan methyl ester; 2) Measure the atomic displacements and changes in electronic distributions that occur in a peptide bond when it is linked by hydrogen bonds to a molecule, specifically the model system of 3-indole propionic acid-H2O; 3) Examine the influence of hydrogen bond formation with water in the reversible tautomerization reaction involving oxindole-H2O in the presence of light; 4) Probe the influence of hydrogen bond formation with water on the inter-molecular dynamics of m-methoxyphenol; and 5) Determine the intramolecular potential energy surface that governs the motion of an alkyl functional group such as -CH3 moiety attached to the N site in N-methylcarbazole and discern how this motion is affected when the assembly is radiated with light. The project will strengthen WSSU's undergraduate students' preparation in advanced spectroscopy technology, and thus, will have a significant impact on WSSU and its commitment to producing more graduates with competencies and degrees in STEM fields. Research will be conducted at WSSU and NIST.

历史黑人学院和大学-本科项目(HBCU-UP)研究启动奖(RIA)为HBCU的STEM初级教员提供支持，他们开始建立研究项目，以及职业生涯中期的教师，他们可能在担任行政职位后重返教职队伍，或者需要重新定向和重建研究项目。教职员工可以在他们的家乡机构、NSF资助的中心、研究密集型机构或国家实验室进行研究。RIA项目有望帮助教师进一步提高研究能力和效率，改善其所在机构的研究和教学，并让本科生参与研究体验。在国家科学基金会的支持下，温斯顿-塞勒姆州立大学(WSSU)将对生物分子结构进行研究，这是理解生物系统过程的关键。这项研究是与美国国家标准与技术研究所(NIST)合作的项目。该项目将提高西大的研究能力和本科生的教育经验。学生将在WSSU和NIST接受指导、培训和研究经验。预计研究和教育努力将扩大STEM中任职人数不足的群体的参与，并支持妇女地位联盟加强和扩大任职人数不足群体的参与的愿景和使命。本研究的目的是：1)通过研究色氨酸甲酯中光致分子内形成的构象偏好，探索几何构型与化学反应动力学之间的直接联系；2)测量当一个分子，特别是3-吲哚丙酸-水的模型体系中，当一个肽键通过氢键连接时，它所发生的原子位移和电子分布的变化；3)在光存在下，考察氧化吲哚-水的可逆互变异构化反应中与水形成氢键的影响；4)探讨与水形成氢键对间甲氧基酚分子间动力学的影响；以及5)确定控制N-甲基咔唑中N位上连接的烷基官能团(如-CH3部分)运动的分子内势能面，并识别当组件受光辐射时这一运动是如何影响的。该项目将加强WSSU本科生在先进光谱技术方面的准备，因此，将对WSSU及其培养更多具有STEM领域能力和学位的毕业生的承诺产生重大影响。研究将在WSSU和NIST进行。