Research Initiation Award: Resonance Raman Spectroscopic Studies on the Dynamic Structures and Long-Range Electron Transfer of Di-Heme
研究启动奖:二血红素动态结构和长程电子转移的共振拉曼光谱研究
基本信息
- 批准号:1505446
- 负责人:
- 金额:$ 19.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Historically Black Colleges and Universities-Undergraduate Program (HBCU-UP) Research Initiation Awards (RIAs) provide support to STEM junior faculty at HBCUs who are starting to build a research program, as well as for mid-career faculty who may have returned to the faculty ranks after holding an administrative post or who needs to redirect and rebuild a research program. Faculty members may pursue research at their home institution, at an NSF-funded Center, at a research intensive institution or at a national laboratory. The RIA projects are expected to help further the faculty member's research capability and effectiveness, to improve research and teaching at his or her home institution, and to involve undergraduate students in research experiences. With support from the National Science Foundation, Tougaloo College will conduct research to understand how heme proteins function in biological systems and what factors regulate their functions. The research project is an interdisciplinary project which will involve students and faculty in the areas of chemistry, physics and biology. The project is expected to expand the research capacity of the College and to promote student and faculty engagement in STEM disciplines. It will contribute to the College's efforts to produce more qualified STEM workers and researchers, especially from underrepresented minority groups.The goals of this project are to: 1) study the dynamic structure of the di-heme enzyme, MauG, and some mutant MauG proteins; 2) determine the relationship between the dynamic properties and the enzyme function; and 3) identify key structural features that control the dynamic structures and long-range electron transfer properties of the enzyme. Resonance Raman and FTIR spectroscopy along with kinetic studies will be used to achieve these goals. Findings from this work will provide clues as to how the protein is self-regulated to perform the catalytic function while protecting itself from oxidative damage and may also help to elucidate the electron-transfer and catalytic mechanism of other multi-active center proteins or protein complexes. This work is expected to extend the understanding of the structure-function relationship, especially the roles of remote residue in electron transfer. This project will also provide training in variable temperature techniques, and protein expression and purification techniques for undergraduates. These are valuable skills that will allow students to distinguish themselves in the job market and/or give students a competitive edge when applying to graduate schools.
历史上的黑人学院和大学本科生计划(HBCU-UP)研究启动奖(RIAs)为HBCU的STEM初级教师提供支持,他们开始建立研究计划,以及职业生涯中期的教师,他们可能在担任行政职务后返回教师队伍,或者需要重新定向和重建研究计划。教师可以在他们的家乡机构,在NSF资助的中心,在研究密集型机构或在国家实验室进行研究。RIA项目预计将有助于进一步提高教师的研究能力和效率,改善他或她的家乡机构的研究和教学,并让本科生参与研究经验。在国家科学基金会的支持下,Tougaloo学院将进行研究,以了解血红素蛋白在生物系统中的功能以及哪些因素调节其功能。该研究项目是一个跨学科的项目,将涉及学生和教师在化学,物理和生物领域。该项目预计将扩大学院的研究能力,并促进学生和教师参与STEM学科。本项目的目标是:1)研究二血红素酶MauG和一些突变MauG蛋白的动力学结构; 2)确定动力学性质与酶功能之间的关系; 3)研究MauG蛋白的动力学性质与酶功能之间的关系。和3)鉴定控制酶的动态结构和远程电子转移性质的关键结构特征。共振拉曼和FTIR光谱沿着动力学研究将用于实现这些目标。这项工作的发现将为蛋白质如何自我调节以执行催化功能同时保护自身免受氧化损伤提供线索,也可能有助于阐明其他多活性中心蛋白质或蛋白质复合物的电子转移和催化机制。这一工作有望加深对结构-功能关系的理解,特别是远程残基在电子传递中的作用。该项目还将为本科生提供变温技术和蛋白质表达与纯化技术的培训。这些都是有价值的技能,将使学生在就业市场上脱颖而出和/或给学生在申请研究生院时的竞争优势。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Manliang Feng其他文献
FIA determination of pyruvate in serum based on direct chemiluminescence oxidation
- DOI:
10.1007/s002160051197 - 发表时间:
1999-02-05 - 期刊:
- 影响因子:3.800
- 作者:
Manliang Feng;Guofang Zhang;Zhujun Zhang - 通讯作者:
Zhujun Zhang
KMnO4-OP Chemiluminescence system for FIA determination of hydrogen peroxide
- DOI:
10.1007/bf01242664 - 发表时间:
1997-03-01 - 期刊:
- 影响因子:5.300
- 作者:
Manliang Feng;Zheng Li;Jiuru Lu;Hailong Jiang - 通讯作者:
Hailong Jiang
Manliang Feng的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Manliang Feng', 18)}}的其他基金
Targeted Infusion Project:Promoting Student Engagement and Success in STEM through a Combined Approach
有针对性的注入项目:通过综合方法促进学生在 STEM 领域的参与和成功
- 批准号:
2205788 - 财政年份:2022
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
相似海外基金
Research Initiation Award: Integrated Approach Toward Examining Fecal Indicator Bacteria Trends in a Coastal Watershed
研究启动奖:检查沿海流域粪便指示细菌趋势的综合方法
- 批准号:
2300319 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Turan-type problems on partially ordered sets
研究启动奖:偏序集上的图兰型问题
- 批准号:
2247163 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: A GNN+BiMCLSTM Based Framework to Model, Predict, and Traceback Malware Strains
研究启动奖:基于 GNN BiMCLSTM 的框架,用于建模、预测和追溯恶意软件菌株
- 批准号:
2300405 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Uncovering and Extracting Biological Information from Nanopore Long-read Sequencing Data with Machine Learning and Mathematical Approaches
研究启动奖:利用机器学习和数学方法从纳米孔长读长测序数据中发现和提取生物信息
- 批准号:
2300445 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Highly Stable Nanoparticle-Doped Metal-Organic Frameworks for Applications in Water Purification
研究启动奖:用于水净化应用的高度稳定的纳米颗粒掺杂金属有机框架
- 批准号:
2344742 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Implementing the Next-Generation IoT Ecosystem with AI Capabilities
研究启动奖:利用人工智能能力实施下一代物联网生态系统
- 批准号:
2200377 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Thermal Decomposition of Four-membered Heterocyclic Peroxides, Data Mining in Nonadiabatic Trajectories, and Chemiexcitation Efficiency
研究启动奖:四元杂环过氧化物的热分解、非绝热轨迹数据挖掘、化学激发效率
- 批准号:
2300321 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Redox Regulated Phosphorylation of BCAT by PKC
研究启动奖:PKC 氧化还原调节 BCAT 磷酸化
- 批准号:
2401097 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Analysis of Glycoprotein Composition and Function of PGE2 EP Receptors in Mammary-derived Cells
研究启动奖:乳腺细胞中 PGE2 EP 受体的糖蛋白组成和功能分析
- 批准号:
2300448 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant
Research Initiation Award: Investigating Instructional Conditions for Robust Learning in Biology
研究启动奖:研究生物学稳健学习的教学条件
- 批准号:
2300454 - 财政年份:2023
- 资助金额:
$ 19.99万 - 项目类别:
Standard Grant