Research Initiation Award: Seasonal Mobilization and Acid Stress Response of Opportunistic Enteric Pathogen Communities in Freshwater Ecosystems

研究启动奖：淡水生态系统中机会性肠道病原体群落的季节性动员和酸性应激反应

• 批准号: 1505477
• 负责人: Gabriel Swenson
• 金额: $ 19.3万
• 依托单位: Paine College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2019-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1505477&HistoricalAwards=false
• 关键词: Research; Initiation; Award; Seasonal; Mobilization

The Historically Black Colleges and Universities-Undergraduate Program (HBCU-UP) Research Initiation Awards (RIAs) provide support to STEM faculty at HBCUs including junior faculty who are starting to build a research program and mid-career faculty returning to the faculty ranks after holding an administrative post or who need to redirect and rebuild a research program. Faculty members may pursue research at their home institution, at an NSF-funded Center, at a research intensive institution or at a national laboratory. The RIA projects are expected to help further the faculty member's research capability and effectiveness, to improve research and teaching at his or her home institution, and to involve undergraduate students in research experiences. Paine College will conduct research on the role that rainfall plays in mobilizing bacterial pathogens which are linked to human health. The project will help build the research capacity at Paine College and will have a major impact on a large population of minority students. The research opportunities and modification of existing curricular offerings will provide undergraduate students with advanced skills in environmental science and enhance teaching and learning at Paine College. In addition, Paine College will enhance its outreach activities to the community by training students majoring in Education who will develop an online teaching module for high schools. The project will integrate water quality surveillance, microcosm studies, environmental sampling, traditional culturing and quantitative molecular analysis to assess the ecological implications of rainfall events on mobilization of four opportunistic enteric pathogens and elicitation of acid stress response (ASR) within a freshwater floodplain. The principle objectives are to: 1) characterize the role of rainfall events in mobilization of sediment associated bacterial communities into a seasonal wetland, and 2) characterize ASR elicitation of the bacterial community within a wetland and riverine system. Findings from this work will strengthen understanding of bacterial community structure and function in aquatic ecosystems, may aid in identification of seasonal environmental "hot spots" of bacterial pathogenicity and may transform paradigms of seasonally influenced bacterial diseases. This project has the potential to transform current mechanistic linkages of opportunistic pathogen mobilization into seasonal wetlands and the contributions of these aquatic ecosystems in conditioning bacterial pathogenicity and community structure.

历史上的黑人学院和大学本科生计划（HBCU-UP）研究启动奖（RIAs）为HBCU的STEM教师提供支持，包括开始建立研究计划的初级教师和职业生涯中期的教师，他们在担任行政职务或需要重新定向和重建研究计划后返回教师队伍。教师可以在他们的家乡机构，在NSF资助的中心，在研究密集型机构或在国家实验室进行研究。RIA项目预计将有助于进一步提高教师的研究能力和效率，改善他或她的家乡机构的研究和教学，并让本科生参与研究经验。潘恩学院将对降雨在动员与人类健康有关的细菌病原体方面所起的作用进行研究。该项目将有助于建立潘恩学院的研究能力，并将对大量少数民族学生产生重大影响。现有课程的研究机会和修改将为本科生提供环境科学方面的高级技能，并加强潘恩学院的教学。此外，潘恩学院将通过培训教育专业的学生来加强对社区的外联活动，这些学生将为高中开发一个在线教学模块。 该项目将综合水质监测、微观研究、环境取样、传统培养和定量分子分析，以评估降雨事件对淡水洪泛区四种肠道机会致病菌的动员和酸应激反应的引发的生态影响。主要目标是：1）表征降雨事件在动员沉积物相关细菌群落进入季节性湿地中的作用，以及2）表征湿地和河流系统中细菌群落的ASR激发。这项工作的结果将加强对水生生态系统中细菌群落结构和功能的理解，可能有助于确定细菌致病性的季节性环境“热点”，并可能改变受季节性影响的细菌疾病的模式。该项目有可能将目前的机制联系的机会病原体动员到季节性湿地和这些水生生态系统的贡献，在空调细菌致病性和社区结构。