UNS: Surfactant Induced Post-Deposition Dispersal of Solid Particles at Liquid/Air Interfaces with Application to Pulmonary Drug Delivery

【参考翻译】：许多治疗呼吸系统疾病的药物都是干粉状的，通过吸入直接进入肺部。吸入疗法的挑战之一是保证精确的剂量均匀地输送到整个肺部。药物颗粒可能优先沉积在某些气道的某些位置，而不能到达其他位置或气道，特别是在阻塞性疾病的情况下。本项目将探索药物颗粒沉积在气道表面液体衬里后促进其扩散的方法。该策略是使用表面活性剂，以颗粒形式与药物颗粒一起递送，以建立沿气道表面液体表面张力的空间变化。表面张力的变化会引起一种叫做马兰戈尼流的流动，这种流动可以夹带药物颗粒并使它们沿着气道表面移动。该项目包括一系列实验，以了解颗粒沿着液体表面运动的动力学，并确定材料特性如何影响药物的最终扩散程度。该项目将探索决定吸入药物颗粒分散程度的因素，包括表面活性剂的性质，如表面张力降低、溶解度和溶解动力学，以及表面活性剂颗粒的润湿性和颗粒的大小。药物颗粒的类似性质将影响在马兰戈尼流中携带的颗粒的运动。将确定与大量共混表面活性剂和药物模型颗粒的沉积模式如何控制大规模粉末分散有关的集体效应，并进行多变量分析以确定控制沉积后分散程度的主要因素。作为联合使用两种颗粒的替代方案，我们将研究一种复合颗粒，它包含药物和表面活性剂，以诱导马兰戈尼流。

CBET - 1510293PI: Garoff, StephenMany drugs to treat respiratory disorders are formulated as dry powders and delivered directly into the lungs by inhalation. One of the challenges in inhalation therapy is guaranteeing the precise dose is delivered uniformly throughout the lungs. The drug particles may preferentially deposit in some locations in certain airways and not reach other locations or airways, especially in cases of obstructive disease. This project will explore ways to promote dispersal of drug particles after they have been deposited onto the liquid lining of airway surfaces. The strategy is to use surfactants, delivered as particles, with the drug particles to establish spatial variations of surface tension in the liquid along airway surfaces. Variations in surface tension induce flows called Marangoni flows that can entrain the drug particles and move them along airway surfaces. The project comprises a series of experiments to understand the dynamics of particle motion along the liquid surface and to determine how material properties influence the final extent of drug dispersal.The project will explore factors that determine the extent of dispersal of inhaled drug particles, including properties of the surfactant, such as surface tension reduction, solubility and kinetics of dissolution as well as wettability of the surfactant particles and size of the particles. Similar properties for the drug particles will affect the motion of the particles entrained in the Marangoni flow. Collective effects related to how the deposition pattern of large numbers of co-mingled surfactant and drug model particles controls large scale powder dispersal will be determined, and a multi-variate analysis will be performed to determine the primary factors that control the extent of post-deposition dispersal. As an alternative to co-administering two kinds of particles, a composite particle that contains both the drug and a surfactant to induce the Marangoni flow will be examined.