UNS: Surfactant Induced Post-Deposition Dispersal of Solid Particles at Liquid/Air Interfaces with Application to Pulmonary Drug Delivery

CBET-1510293PI：加洛夫，斯蒂芬许多治疗呼吸系统疾病的药物都是以干粉的形式配制，并通过吸入直接进入肺部。吸入疗法的挑战之一是确保精确的剂量在整个肺内均匀传递。药物颗粒可能优先沉积在某些呼吸道的某些位置，而不会到达其他位置或呼吸道，特别是在阻塞性疾病的情况下。该项目将探索在药物颗粒沉积到呼吸道表面的液体衬里后促进其扩散的方法。该策略是使用表面活性剂，以颗粒的形式与药物颗粒一起使用，以建立液体中沿呼吸道表面的表面张力的空间变化。表面张力的变化会引起被称为Marangoni流的流动，这种流动可以携带药物颗粒并沿着呼吸道表面移动。该项目包括一系列实验，以了解颗粒沿液体表面的运动动力学，并确定材料性质如何影响药物分散的最终程度。该项目将探索决定吸入药物颗粒分散程度的因素，包括表面活性剂的性质，如表面张力降低、溶解度和溶解动力学，以及表面活性剂颗粒的润湿性和颗粒大小。药物颗粒的类似性质将影响携带在Marangoni流中的颗粒的运动。与大量共混表面活性剂和药物模型颗粒的沉积模式如何控制大规模粉末分散有关的集体效应将被确定，并将进行多变量分析以确定控制沉积后分散程度的主要因素。作为两种颗粒共同给药的替代方案，将研究一种同时包含药物和表面活性剂以诱导Marangoni流动的复合颗粒。

CBET - 1510293PI: Garoff, StephenMany drugs to treat respiratory disorders are formulated as dry powders and delivered directly into the lungs by inhalation. One of the challenges in inhalation therapy is guaranteeing the precise dose is delivered uniformly throughout the lungs. The drug particles may preferentially deposit in some locations in certain airways and not reach other locations or airways, especially in cases of obstructive disease. This project will explore ways to promote dispersal of drug particles after they have been deposited onto the liquid lining of airway surfaces. The strategy is to use surfactants, delivered as particles, with the drug particles to establish spatial variations of surface tension in the liquid along airway surfaces. Variations in surface tension induce flows called Marangoni flows that can entrain the drug particles and move them along airway surfaces. The project comprises a series of experiments to understand the dynamics of particle motion along the liquid surface and to determine how material properties influence the final extent of drug dispersal.The project will explore factors that determine the extent of dispersal of inhaled drug particles, including properties of the surfactant, such as surface tension reduction, solubility and kinetics of dissolution as well as wettability of the surfactant particles and size of the particles. Similar properties for the drug particles will affect the motion of the particles entrained in the Marangoni flow. Collective effects related to how the deposition pattern of large numbers of co-mingled surfactant and drug model particles controls large scale powder dispersal will be determined, and a multi-variate analysis will be performed to determine the primary factors that control the extent of post-deposition dispersal. As an alternative to co-administering two kinds of particles, a composite particle that contains both the drug and a surfactant to induce the Marangoni flow will be examined.