STTR Phase I: Development of an Objective Tremor Detection System to Improve Neonatal Abstinence Syndrome Outcomes

STTR 第一阶段：开发客观震颤检测系统以改善新生儿戒断综合症的结果

• 批准号: 1521068
• 负责人: Michael Abbott
• 金额: $ 22.49万
• 依托单位: Cambrian Design and Development
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1521068&HistoricalAwards=false
• 关键词: STTR; Phase; Development; Objective; Tremor

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project will be to provide quantitative, actionable data that enables safer, more effective treatment of infants with Neonatal Abstinence Syndrome. The medical community is frustrated with the decades-old subjective assessment tools at their disposal. Technology has progressed to a point where an objective alternative is now possible. While many medical technologies reduce physician-patient involvement, this approach will increase the quality of physician interactions, improve patient outcome, and save an estimated $15,000 per patient by reducing length of stay for those patients by as much as 50%. This estimated healthcare savings in the United States alone is $402 million annually. While this technology is focused on Neonatal Abstinence Syndrome, the physical tremors being investigated are similar in nature to those associated with other neurological disorders. A successful outcome of this project will enable future research to improve the outcomes for patients suffering from other neurological disorders such as ALS, Cerebral Palsy, and Parkinson?s. Success with Neonatal Abstinence Syndrome is sufficient to provide sustainable commercial success after product launch.The proposed project uses miniature wireless sensors to detect, differentiate, and quantify physiological tremors caused by withdrawal in infants suffering from Neonatal Abstinence Syndrome. A successful outcome will be a measurement system to replace key indicators of the subjective Finnegan Scoring System with objective data. The project objectives are to design the sensors, optimize placement and number of sensors, and design signal processing algorithms to allow discrimination between general infant movements and NAS tremors as measured on patient limbs and/or torso. Tremor measurements will be correlated to traditional Finnegan Scoring assessments as part of the validation process. The Virginia Department of Health reported that in 2012, 394 cases of NAS were found, representing approximately 15% of all opiate addictions. The cost of treating these cases was $16.6MM, or approximately $42k per case, driven primarily by the average length of stay of 10 days, five to six days less than the national average for similar patient populations. Two additional, independent data sources estimate a total available US market for treatment to be $805MM. Feedback from more than 100 doctors and nurses indicates this approach can reduce length of stay as by as much as 50%, saving an estimated $300MM.

这个小企业技术转让（STTR）第一阶段项目的更广泛的影响/商业潜力将是提供定量的、可操作的数据，从而能够更安全、更有效地治疗患有新生儿禁欲综合征的婴儿。医学界对几十年前的主观评估工具感到沮丧。技术已经发展到一个客观的替代品现在是可能的。虽然许多医疗技术减少了医生与患者的参与，但这种方法将提高医生互动的质量，改善患者的预后，并通过将这些患者的住院时间缩短50%，为每位患者节省约15，000美元。 据估计，仅在美国，每年就可节省4.02亿美元的医疗费用。虽然这项技术的重点是新生儿禁欲综合征，但正在研究的身体震颤在性质上与其他神经系统疾病相关的震颤相似。该项目的成功结果将使未来的研究能够改善患有其他神经系统疾病（如ALS，脑瘫和帕金森病）的患者的预后。S.新生儿禁欲综合症的成功足以在产品发布后提供可持续的商业成功。拟议的项目使用微型无线传感器来检测，区分和量化患有新生儿禁欲综合症的婴儿因戒断引起的生理震颤。一个成功的结果将是一个衡量系统，以客观数据取代主观芬尼根评分系统的关键指标。该项目的目标是设计传感器，优化传感器的放置和数量，并设计信号处理算法，以允许在患者肢体和/或躯干上测量的一般婴儿运动和NAS震颤之间进行区分。作为验证过程的一部分，震颤测量值将与传统Finnegan评分评估相关。弗吉尼亚州卫生部报告说，2012年发现了394例NAS病例，约占所有阿片类药物成瘾的15%。治疗这些病例的费用为1660万美元，即每个病例约4.2万美元，主要是由于平均住院时间为10天，比类似患者人群的全国平均水平少5至6天。另外两个独立的数据来源估计，美国治疗市场的总价值为8.05亿美元。来自100多名医生和护士的反馈表明，这种方法可以将住院时间缩短多达50%，估计可节省3亿美元。