MRI:Acquisition of a Beckman ProteomeLab-XLI Analytical Ultracentrifuge to Enhance Research and Training

MRI：购买 Beckman ProteomeLab-XLI 分析超速离心机以加强研究和培训

• 批准号: 1530862
• 负责人: Nicholas Dickenson
• 金额: $ 27.17万
• 依托单位: Utah State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1530862&HistoricalAwards=false
• 关键词: MRI; Acquisition; Beckman; ProteomeLab; XLI

An award is made to Utah State University to acquire a new Beckman ProteomeLab XLI analytical ultracentrifuge (AUC) to support research and training. The AUC will support the research programs of seven different laboratories and be available to other users within the university and neighboring institutions. At USU, the instrument will be used to provide hands-on training in cutting-edge molecular techniques to undergraduate, graduate and postdoctoral researchers, and become an integral part of the educational and outreach efforts in the Chemistry and Biochemistry department. The analytical ultracentrifuge will be used to study the in solution properties of macromolecular complexes including determining accurate molecular weights, heterogeneity and stoichiometry. At USU, the analytical ultraentrifuge will be used to support the research of the PI and Co-PI's to investigate: (1) the mechanism of action of ATP-dependent motor proteins; (2) the assembly of Type III secretion systems in pathogens; (3) the oxidation based control of proteins; (4) the assembly mechanism of RNA; (5) the Iron protein cycle; (6) antimicrobial action of amphiphilic aminoglycosides; and (7) the development of therapeutics for Amyloid Diseases.

授予犹他州州立大学一个新的Beckman ProteomeLab XLI分析超浓缩仪（AUC），以支持研究和培训。AUC将支持七个不同实验室的研究计划，并可供大学和邻近机构的其他用户使用。在USU，该仪器将用于为本科生，研究生和博士后研究人员提供尖端分子技术的实践培训，并成为化学和生物化学系教育和推广工作的一个组成部分。分析超离心将用于研究大分子复合物的溶液性质，包括确定准确的分子量，异质性和化学计量。在USU，分析超电泳将用于支持PI和Co-PI的研究，以研究：（1）ATP依赖性马达蛋白的作用机制;（2）病原体中III型分泌系统的组装;（3）基于氧化的蛋白质控制;（4）RNA的组装机制;（5）铁蛋白循环;（6）蛋白质合成;（7）蛋白质合成;（8）蛋白质合成;（9）蛋白质合成。（6）两亲性氨基糖苷类的抗菌作用;（7）淀粉样蛋白疾病治疗药物的开发。