MRI:Acquisition of a Beckman ProteomeLab-XLI Analytical Ultracentrifuge to Enhance Research and Training

犹他州立大学获得了一台新的Beckman ProteomeLab XLI分析超速离心机(AUC)，以支持研究和培训。AUC将支持七个不同实验室的研究计划，并向大学内和邻近机构的其他用户开放。在密歇根州立大学，该仪器将用于为本科生、研究生和博士后研究人员提供尖端分子技术方面的实践培训，并成为化学和生物化学系教育和推广工作的组成部分。分析超速离心机将用于研究大分子络合物的溶液性质，包括测定准确的相对分子质量、非均质性和化学计量。在华盛顿大学，分析性超滤将被用来支持PI和Co-PI的研究，以研究：(1)依赖于ATP的马达蛋白的作用机制；(2)病原体中III型分泌系统的组装；(3)蛋白质的氧化控制；(4)RNA的组装机制；(5)铁蛋白循环；(6)两亲性氨基糖苷类的抗菌作用；以及(7)淀粉样病的治疗方法的发展。

An award is made to Utah State University to acquire a new Beckman ProteomeLab XLI analytical ultracentrifuge (AUC) to support research and training. The AUC will support the research programs of seven different laboratories and be available to other users within the university and neighboring institutions. At USU, the instrument will be used to provide hands-on training in cutting-edge molecular techniques to undergraduate, graduate and postdoctoral researchers, and become an integral part of the educational and outreach efforts in the Chemistry and Biochemistry department. The analytical ultracentrifuge will be used to study the in solution properties of macromolecular complexes including determining accurate molecular weights, heterogeneity and stoichiometry. At USU, the analytical ultraentrifuge will be used to support the research of the PI and Co-PI's to investigate: (1) the mechanism of action of ATP-dependent motor proteins; (2) the assembly of Type III secretion systems in pathogens; (3) the oxidation based control of proteins; (4) the assembly mechanism of RNA; (5) the Iron protein cycle; (6) antimicrobial action of amphiphilic aminoglycosides; and (7) the development of therapeutics for Amyloid Diseases.