NSF/FDA SIR: Non-invasive assessment of neuromechanical outcomes from next generation peripheral nerve implants

PI：Shah，Sameer建议编号：1541908 PI建议为周围神经电极制定先进的评估标准，这种电极可能会改变神经结构、生物力学和生理功能，使用非侵入性成像方式。用Micro-CT和超短回波时间磁共振成像(UTE)研究袖套电极(CES)和犹他州倾斜电极阵列(USEAs)放置在大鼠髋部和膝关节(大腿中部)坐骨神经上的结构-功能效应。在FDA从事该项目的研究生和本科生所接受的培训将是非常出色的。每个研究目标都描述了适用于高中生以及本科生和研究生的实验方法。

PI: Shah, Sameer Proposal Number: 1541908 The PI proposes to develop advanced evaluation criteria for peripheral nerve electrodes, which may alter nerve structure, biomechanics and physiological function, using non-invasive imaging modalities. Micro-CT and ultra short echo time MRI (UTE) will be used to study the structure-function effects of cuff electrodes (CEs) and Utah Slanted Electrode Arrays (USEAs) placed on the sciatic nerve between the hip and the knee (mid thigh) of rats. The training received by the graduate student and undergraduate student working on the project at the FDA will be excellent. Each research Objective describes experimental methods involved that would be appropriate for high school students as well as undergraduate and graduate students.