I-Corps: PlusOne: Whole Home Non-Contact Breathing Monitor to Prevent Overdose Death

服用处方阿片类止痛药的患者在睡觉时，呼吸频率会减慢到危险水平，然后停止呼吸。药物过量问题已经成为一种流行病，每年有4万美国人死亡，比20年前死亡人数多5倍，现在是美国意外死亡的主要原因。该项目建议使用PlusOne监测器来监测家中有处方药过量风险的人，这是一个部署在家中的无线传感器网络，可以收集和处理无线电频道数据，以便持续估计呼吸频率。传感器是非接触式的，并且一直处于开启状态，无论用户在家里哪里，传感器都可以工作。如果一个人“静止”，呼吸频率低到危险的程度，系统就会通过短信或电话提醒看护人，或者自动拨打911。尽管在美国，处方药过量死亡的发生率高于机动车死亡，但没有开发出任何安全系统来降低过量死亡率。如果成功，这个商业系统将大大降低死亡率。除了处方药安全市场，I-Corps团队认为非接触式呼吸监测系统在个人健康监测、婴儿监测和搜救方面也有应用。该团队假设，戒毒康复中心将会重视PlusOne监测器所提供的安全性，并会在病人出院后花钱将其安置在他们的家中。虽然现有的其他产品也可以监测呼吸频率，但它们需要人体与设备相连，或者在设备的一小段距离内。PlusOne系统是一个网络，监测每一对部署的传感器之间的无线电波传播通道，形成一个完全覆盖家庭的网格。没有其他产品能够始终打开并覆盖整个家庭。在这个项目中，团队将执行客户细分验证，以确定如何成功地将该安全产品推向市场& & #894；(2)进一步开发用于客户和合作伙伴演示的原型；(3)在人体受试者研究中进行进一步验证。如果成功，该团队将对该技术进行投资，未来的监管批准，并在市场上取得成功，并通过这样做，能够为处方阿片类药物过量的最大危险人群提供安全系统。

A patient taking a prescription opioid pain reliever, while sleeping, can have ones' breathing rate slow to a dangerous level and then stop. The drug overdose problem has become an epidemic with 40,000 U.S. deaths annually, five times more deadly than twenty years ago, and now is the leading cause of accidental death in the U.S. This project proposes to monitor people at risk of prescription drug overdose in their home using the PlusOne monitor, a wireless network of sensors deployed in a home that collect and process radio channel data in order to continuously estimate breathing rate. The sensors are noncontact and always on, and work wherever the person is in his or her home. If a person is "still" and the breathing rate is dangerously low, the system alerts a caretaker by text or call, or automatically calls 911. Although prescription drug overdose deaths happen at a higher rate than motor vehicle deaths in the US, no safety systems have been developed to reduce the overdose death rate. If successful, this commercial system could dramatically reduce the death rate. Beyond the prescription drug safety market, this I-Corps team believes a noncontact breathing monitoring system has application in personal health monitoring, baby monitoring, and search and rescue.This team hypothesizes that drug rehabilitation centers will value the improved safety that the PlusOne monitor provides and will pay to deploy it in the homes of their patients when they are released. While other products exist to monitor breathing rate, they require the person to be physically connected to, or within a short distance of the device. The PlusOne system is a network that monitors the radio wave propagation channel between each pair of deployed sensors, forming a mesh that fully covers a home. No other product has the capability to be always on and cover an entire home. In this project the team will perform customer segment validation to determine how to successfully bring this safety product to market; (2) further develop a prototype for customer and partner demonstrations; and (3)perform further validation in human subjects studies. If successful, the team will position the technology for investment, future regulatory approval, and success in the market, and in so doing, be able to provide a safety system for people who are in greatest danger of a prescription opioid overdose.