Research Initiation Award: Toward Bionanoscience - Binding of Amino Acids with Graphene and N-doped Graphene

研究启动奖：迈向生物纳米科学——氨基酸与石墨烯和氮掺杂石墨烯的结合

• 批准号: 1601071
• 负责人: Dinadayalane Tandabany
• 金额: $ 30万
• 依托单位: Clark Atlanta University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1601071&HistoricalAwards=false
• 关键词: Research; Initiation; Award; Toward; Bionanoscience

The Historically Black Colleges and Universities-Undergraduate Program (HBCU-UP) Research Initiation Awards (RIAs) provide support to STEM junior faculty at HBCUs who are starting to build a research program, as well as for mid-career faculty who may have returned to the faculty ranks after holding an administrative post or who needs to redirect and rebuild a research program. Faculty members may pursue research at their home institution, at an NSF-funded Center, at a research intensive institution or at a national laboratory. The RIA projects are expected to help further the faculty member's research capability and effectiveness, to improve research and teaching at his or her home institution, and to involve undergraduate students in research experiences. With support from the National Science Foundation, Clark Atlanta University (CAU) will conduct research aimed at understanding the binding properties of graphene and nitrogen-doped (N-doped) graphene with amino acids that may be useful for the development of biosensors. This project will be used to enhance teaching and learning at CAU and thus, help to prepare the next-generation of underrepresented African American undergraduate students by training them in the research area of Bionanoscience at CAU. The research and educational efforts will contribute to the University's goal to increase research related to computational sciences and to increase student engagement with faculty outside of the classroom through undergraduate research. In addition, the combined research training and education for the CAU students will result in graduates that are well-prepared to manage graduate school and well-qualified to compete in a diverse workforce.The goal of the proposed study is to investigate the binding of all twenty naturally occurring amino acids (AAs) with graphene at gas phase and aqueous medium using quantum chemical calculations. The computations will be extended to examine the binding of AAs with nitrogen doped (N-doped) graphene to gain insight on the effect and the type of N-doping in graphene. The specific aims of this project are to: (1) obtain a fundamental understanding of the binding of amino acids (AAs) with graphene and N-doped graphene through computational investigations in gas phase and aqueous medium; (2) compare the computed results with the experimental data; and (3) prepare the next-generation of underrepresented African American undergraduate students by training them in the research area of Bionanoscience at CAU. The findings from this study will provide significant knowledge that will be useful for the development of biosensors and drug delivery applications using graphene-based nanomaterials. In addition, the proposed research will enhance our current knowledge on how to engineer graphene for biological applications. This project will be conducted in collaboration with Jackson State University.

历史上黑人学院和大学本科项目（HBCU-UP）研究启动奖（RIA）为HBCU开始建立研究项目的STEM初级教师以及可能重返教师队伍的职业中期教师提供支持担任行政职务或需要重新定向和重建研究项目。教师可以在他们的家乡机构，在NSF资助的中心，在研究密集型机构或在国家实验室进行研究。RIA项目预计将有助于进一步提高教师的研究能力和效率，改善他或她的家乡机构的研究和教学，并让本科生参与研究经验。在美国国家科学基金会的支持下，克拉克亚特兰大大学（CAU）将开展研究，旨在了解石墨烯和氮掺杂（N掺杂）石墨烯与氨基酸的结合特性，这可能有助于生物传感器的开发。该项目将用于加强教学和学习在CAU，从而帮助准备下一代的代表性不足的非洲裔美国本科生，通过培训他们在生物纳米科学的研究领域在CAU。研究和教育工作将有助于大学的目标，增加与计算科学相关的研究，并通过本科生研究增加学生与教师在课堂外的参与。 此外，CAU学生的研究培训和教育相结合，将使毕业生做好管理研究生院的充分准备，并有资格在多样化的劳动力中竞争。拟议研究的目标是使用量子化学计算研究所有20种天然存在的氨基酸（AAs）与石墨烯在气相和水介质中的结合。计算将被扩展到检查的氮掺杂（N-掺杂）石墨烯的原子吸收光谱的结合，以获得洞察的效果和类型的N-掺杂在石墨烯。本项目的具体目标是：（1）通过气相和水相介质中的计算研究，获得对氨基酸（AAs）与石墨烯和氮掺杂石墨烯结合的基本认识;（2）将计算结果与实验数据进行比较;及（3）准备下一个-通过对中国农业大学生物纳米科学研究领域的培训，培养代表性不足的非裔美国本科生。这项研究的结果将提供重要的知识，这将有助于使用石墨烯基纳米材料开发生物传感器和药物输送应用。此外，拟议的研究将增强我们目前关于如何将石墨烯工程化用于生物应用的知识。该项目将与杰克逊州立大学合作进行。