MRI: Acquisition of a BioSpectrum Advanced Imaging System for Interdisciplinary Research and Undergraduate Research Training

纽约州立大学Geneseo分校将获得UVP BioSpectrum 815成像系统。这一先进的成像系统将通过其更高的数据收集灵敏度来加速生物学、生物化学和化学领域的研究，并将允许在免疫学和细胞色素生物学领域扩大数据采集，细胞色素生物学是与蛋白质结合的含铁化合物的生物制剂。它将捕捉和分析标有紫外线荧光或显色剂标签的蛋白质和DNA凝胶的高分辨率图像。此外，它还将允许在同一凝胶上检查标记的核酸和蛋白质目标，并将对实验室培养的细菌和真核细胞克隆进行成像。每年将有30多名本科生在教师领导的研究项目中使用该成像仪，每年有200多名本科生在生态学、遗传学、分子和细胞生物学、免疫学、化学、生物化学、神经生物学和环境科学等领域的实验室课堂上使用该成像仪。UVP BioSpectrum 815成像系统将立即被纳入一些正在进行的项目中，包括：(1)研究超强类固醇对外阴致癌的影响，将揭示改变关键转录因子的机制；(2)调查布鲁氏锥虫的核酸甲基化，以解决对生物体DNA碱基全谱缺乏了解的问题；(3)研究控制视网膜生长和发育的分子和遗传机制，这将有助于了解与视网膜发育缺陷有关的基因突变；(4)研究主要的减数分裂转录因子在丝状真菌生长中的转录和翻译调节；(5)研究c型细胞色素的生物发生和功能，进一步了解含铁或含血红素的蛋白质的合成；以及(6)研究治疗用小分子与其核酸靶标的相互作用，这将有助于更好地理解分子相互作用。预计纽约州立大学Geneseo生物系和化学系的更多调查人员以及至少一名心理学系的调查人员将使用该仪器。该仪器将立即纳入生物系和化学系教授的几门实验室课程。

An award is made to the State University of New York at Geneseo to acquire a UVP BioSpectrum 815 imaging system. This advanced imaging system will accelerate research in the areas of Biology, Biochemistry and Chemistry through its increased sensitivity for data collection and will allow for expanded data acquisition in the areas of immunology and cytochrome biology, the biologics of iron-containing compounds bonded to a protein. It will capture and analyze high resolution images of protein and DNA gels that are labeled with UV fluorescent, or color reagent tags. In addition it will allow for examination of tagged nucleic acid and protein targets on the same gel and will also image laboratory-grown bacterial and eukaryotic colonies. More than 30 undergraduates per year will use the imager in faculty-led research projects and more than 200 undergraduates per year will utilize the imager in their laboratory classwork in the areas of ecology, genetics, molecular and cellular biology, immunology, chemistry, biochemistry, neurobiology and environmental sciences. The UVP BioSpectrum 815 Imaging System will be immediately incorporated into a number of ongoing projects including: (1) studies of the effects of ultrapotent steroid use on vulvar carcinogenesis that will shed light on the mechanisms involved in altering key transcription factors; (2) investigations into nucleic acid methylation in Trypanosoma brucei that will address a lack of knowledge on the full repertoire of DNA bases in organisms; (3) investigation into the molecular and genetic mechanisms controlling the growth and development of the retina, which is leading to an understanding of gene mutations associated with developmental defects of the retina; (4) investigation of the transcriptional and translational regulation of a major meiotic transcription factor as applied to growth of filamentous fungi; (5) investigations into the biogenesis and function of c-type cytochromes, furthering knowledge on the synthesis of iron-, or heme-containing proteins; and (6) studies into the interaction of therapeutically small molecules with their nucleic acid targets, which will lead to an improved understanding of molecular interactions. It is expected that additional investigators in the Biology and Chemistry Departments as well as at least one in the Psychology Department at SUNY Geneseo will utilize the instrument. The instrument will be immediately incorporated into several laboratory courses that are taught by both the Biology and Chemistry Departments.