Catalytic hydrodefluorination using cyclopentadienyl complexes of group 4 and rare earth metals

使用第 4 族和稀土金属的环戊二烯基络合物催化加氢脱氟

• 批准号: 225298454
• 负责人: Professor Dr. Dieter Lentz
• 金额: --
• 依托单位: Abteilung Anorganische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/225298454?language=en
• 关键词: Catalytic; hydrodefluorination; using; cyclopentadienyl; complexes

The high bond energy and the kinetic inertness of C-F bonds have made the functionalization of organofluorine compounds one of the major challenges in modern organometallic chemistry. Bis(cyclopentadienyl)difluoridotitanium(IV) turned out to be a very effective precatalyst for the catalytic hydrodefluorination of fluoro alkenes like hexafluoropropene, using silanes as hydride source. By expansion of the substrate scope, this method is to be established as a tool for the synthesis of different partially fluorinated organic compounds. A systematic optimization shall result in a better performance, selectivity and functional group tolerance. This aim requires a detailed study of the reaction mechanism and influences of the ligands and the metal by experimental and theoretical methods.

碳氟键的高键能和动力学惰性使得有机氟化合物的功能化成为现代有机金属化学的主要挑战之一。结果表明，双（环戊二烯基）二氟钛（IV）是使用硅烷作为氢化物源催化六氟丙烯等氟烯烃加氢脱氟的一种非常有效的预催化剂。通过扩大底物范围，将该方法建立为合成不同部分氟化有机化合物的工具。系统的优化将带来更好的性能、选择性和官能团容忍度。这一目标需要通过实验和理论方法对配体和金属的反应机理和影响进行详细的研究。