Technical Exchange Meeting on Semiconductor Platforms for Synthetic Biology and Hybrid Bioelectronic Systems, July27-28,2016 at Georgia Institute of Technology in Atlanta, GA

最近，人们对混合生物越来越感兴趣--半导体平台可以利用自然/合成生物过程和半导体技术，并实现远远超出传统电子设备的新型传感、驱动和信号处理功能。在这样的混合平台中，活的细胞和组织可以起到生物前端的作用，利用内源过程来执行生物感知、驱动、信号处理、合成和能量收集。同时，底层的半导体平台可以形成一个用于信息计算、控制、通信和存储的“半导体后端”。此外，信息和能源的实时双向接口方案可以将生物层和半导体层紧密耦合，并有可能形成混合闭环反馈系统。然而，目前对这类话题的研究还处于起步阶段。因此，本次技术交流会的组织重点是合成生物和混合生物电子系统的半导体平台。这次会议将于2016年7月在佐治亚理工学院举行，为期一天半。生物-半导体混合系统可广泛应用于具有突破性科学、经济和社会影响的关键应用领域。这些混合设备可以提供前所未有的能力，远远超过传统的纯电子设备。这些关键应用包括危险检测、药物筛选、干细胞培养、生物执行器、制造商或机器人、生物能源采集、生物-非生物混合计算系统以及研究神经元/神经元网络。将广泛传播拟议会议的结果。拟议的技术交流会也将为研究生和本科生提供一个完美的外展和教育机会。研究界认为，拟议的技术交流会是一次及时的行动呼吁。它将制定未来的研究议程，使混合生物/纳米电子设备/系统的科学探索成为可能，并确保国家长期无可争议的技术领先地位。此外，本次会议汇聚了顶尖的学术和工业科学家，就未来生物-半导体混合器件/系统的关键科学挑战进行讨论、辩论并寻求共识；这次会议将为智力追求和识别重大/限制性科学挑战提供一个极好的机会。技术交流会旨在讨论以下暂定议题。主题1.不同半导体平台/纳米材料的生物兼容性研究和最新的生物兼容封装技术。主题2.半导体平台和合成生物学之间具有高时空分辨率的实时双边接口(传感和驱动)。主题3.基于合成生物学的传感、计算、合成和能量采集以及与半导体平台的潜在混合集成。专题4.半导体/合成生物混合系统的未来高影响应用。所有这些主题都与合成生物学和混合生物电子系统的半导体平台密切相关。此外，这次会议将是讨论和探索混合生物/纳米电子设备/系统潜在的高影响应用的理想论坛。

Recently, there has been an increasing interest in hybrid biology-semiconductor platforms that can leverage both natural/synthetic biological processes and semiconductor technologies, and achieve novel sensing, actuation, and signal processing functionalities far beyond conventional electronics-only devices. In such hybrid platforms, living cells and tissues can function as a "Biological Front-End", which utilizes the endogenous processes to perform biological sensing, actuation, signal processing, synthesis, and energy harvesting. In parallel, the underlying semiconductor platforms can form a "Semiconductor Back-End" for information computation, control, communication, and storage. Furthermore, real-time two-way interfacing schemes, for both information and energy, can closely couple the biology and semiconductor layers and potentially form hybrid closed-loop feedback systems. However, current research on such topics is still in its stage of infancy. Therefore, this technical exchange meeting is organized to focus on semiconductor platforms for synthetic biology and hybrid bioelectronic systems. This meeting will be one and a half day event organized at the Georgia Institute of Technology in July 2016. The hybrid biology-semiconductor systems can be employed in a broad spectrum of critical applications with ground-breaking scientific, economical, and societal impacts. These hybrid devices can offer unprecedented capabilities far beyond conventional electronics-only devices. These key applications include hazard detection, drug screening, stem cell culture, biological actuators, manufacturers, or robots, biological energy harvesting, biotic-abiotic hybrid computing systems, and studying neurons/neuron networks. The results of the proposed meeting will be widely disseminated. The proposed technical exchange meeting will also serve as a perfect outreach and education opportunity for graduate and undergraduate students.It is believed by the research community that the proposed technical exchange meeting is a timely call to action. It will develop future research agendas that enable the scientific explorations on hybrid biological/nano-electronic devices/systems and insure the Nation long-term uncontested technology leadership. Moreover, this meeting brings together leading academic and industrial scientists to discuss, debate and seek consensus on key scientific challenges on future biology-semiconductor hybrid devices/systems; this meeting will provide an excellent opportunity for intellectual pursuit and discernment of important/limiting scientific challenges. The technical exchange meeting aims to cover the following tentative topics. Topic 1. Biocompatibility studies of different semiconductor platforms/nanomaterials and state-of-the-art biocompatible packaging technologies. Topic 2. Real-time bilateral interface (sensing and actuation) with high spatiotemporal resolution between semiconductor platforms and synthetic biology. Topic 3. Synthetic biology based sensing, computation, synthesis, and energy harvesting and potential hybrid integrations with semiconductor platforms. Topic 4. Future high-impact applications of semiconductor/synthetic-biology hybrid systems. All of these topics are closely related with semiconductor platforms for synthetic biology and hybrid bioelectronics systems. Furthermore, this meeting will be an ideal forum to discuss and explore the potential high-impact applications of the hybrid biological/nano-electronic devices/systems.