Translational studies to specify attentional deficits in schizophrenia: amplificatory and inhibitory mechanisms in multisensory information selection

注意是描述信息选择的神经认知过程的心理学构念。因此，在相关和不相关的信息在认知处理中争夺优先权的情况下，注意力变得特别重要。因此，在子程序水平，放大机制，以增加任务相关的处理，可以区分抑制机制，减少任务无关的信息的处理。本研究在前人工作的基础上，利用最新的神经影像学技术，对放大和抑制注意子过程进行了系统的研究。计划的调查包括，首先，一系列基本的认知神经科学研究的神经实施的注意力子过程在健康的人类大脑。第二，翻译临床研究应确定潜在的障碍，这些注意力的子过程在精神分裂症患者，在特定的病理生理相关的良好建立的选择性注意力缺陷，在这种疾病。因此，拟议的调查将提供重要的新的见解，在健康的大脑信息处理的神经机制，以及在精神分裂症的注意力缺陷的病理生理学。

Attention is a psychological construct to describe neurocognitive processes of information selection. Accordingly, attention becomes especially important in situations in which relevant and irrelevant information compete for priority in cognitive processing. Thereby, at the sub-procedural level, amplificatory mechanisms to increase task-relevant processing can be distinguished from inhibitory mechanisms that decrease the processing of task-irrelevant information. Building upon prior work of the proposers, the present study project aims at a systematic investigation of amplificatory and inhibitory attentional sub-processes by state-of-theart neuroimaging techniques. The planned investigations comprise, first, a series of basic cognitive neuroscientific studies on the neural implementation of attentional sub-processes in the healthy human brain. Second, translational clinical investigations should define potential disturbances of these attentional subprocesses in schizophrenia patients, in terms of specific pathophysiological correlates of the well established selective attentional deficits in this disorder. Hence, the proposed investigations will provide important new insights in the neural mechanisms of information processing in the healthy brain as well as in the pathophysiology of attentional deficits in schizophrenia.