I-Corps: Natural Product-based, Mechanically-diverse Degradable Engineering Materials

I-Corps：基于天然产物的机械多样化可降解工程材料

• 批准号: 1645581
• 负责人: Karen Wooley
• 金额: $ 5万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1645581&HistoricalAwards=false
• 关键词: Corps; Natural; Product; based; Mechanically

The broader impact/commercial potential of this I-Corps project will be the use of degradable natural product-based materials for the reduction of pollution stemming from lost and discarded plastic goods in the environment. Natural product-based polycarbonates have significant potential environmental and societal impact, as they are made from natural products, reducing the dependency of polymeric materials on petroleum-based feedstocks. Another advantage of these polycarbonate materials is that upon degradation, they reproduce natural products and carbon dioxide, giving the potential for environmental resorption. The commercial potential of degradable polymer materials is extensive when they can be produced rapidly and have broadly-tunable mechanical properties, allowing for their use in a diverse range of commercial products, from disposable food containers to high performance engineering materials.This I-Corps project involves a safe, sustainable solution to the challenge of durable plastic materials that can foul and damage marine and other environments. This I-Corps technology involves the use of abundant natural products to produce polymer networks and composite materials having a range of physical and mechanical properties, and a programmed disintegration pathway. Synthetic strategies have been developed to transform glucose, quinic acid, and other natural products into multi-functional monomers that can be rapidly polymerized using photochemically- or thermally-initiated crosslinking to afford unique polycarbonate materials. Through the use of molds during crosslinking, these materials can be fabricated into many shapes and sizes. Polycarbonates with mechanical characteristics from a rubbery elastomer to a rigid plastic can be achieved by varying the crosslinking conditions. Hydrolytic degradation times can be tuned, depending on the crosslink density and hydrophilicity. These materials have also demonstrated no negative effects on the growth of cells. In summary, a combination of simple fabrication techniques and rapid, reliable chemistry can be employed to obtain a versatile and non-toxic natural family of materials with a breadth of physical and mechanical properties, generating commercial promise in a wide range of applications.

I-Corps项目的更广泛影响/商业潜力将是使用可降解的天然产品材料，以减少丢失和丢弃的塑料制品对环境造成的污染。基于天然产品的聚碳酸酯具有重大的潜在环境和社会影响，因为它们是由天然产品制成的，减少了聚合物材料对石油基原料的依赖。这些聚碳酸酯材料的另一个优点是，在降解时，它们可以再生自然产物和二氧化碳，从而有可能被环境吸收。可降解聚合物材料的商业潜力是广泛的，因为它们可以快速生产，具有广泛可调的机械性能，允许它们在各种商业产品中使用，从一次性食品容器到高性能工程材料。这个I-Corps项目涉及一个安全、可持续的解决方案，以应对耐用塑料材料可能污染和破坏海洋和其他环境的挑战。I-Corps的这项技术涉及到使用丰富的天然产物来生产具有一系列物理和机械性能的聚合物网络和复合材料，以及一个程序化的分解途径。合成策略已经发展到将葡萄糖，奎宁酸和其他天然产物转化为多功能单体，可以使用光化学或热引发交联快速聚合，以提供独特的聚碳酸酯材料。通过在交联过程中使用模具，这些材料可以被制造成许多形状和尺寸。从橡胶弹性体到刚性塑料的机械特性的聚碳酸酯可以通过改变交联条件来实现。水解降解时间可以调整，取决于交联密度和亲水性。这些材料也被证明对细胞生长没有负面影响。总之，简单的制造技术和快速、可靠的化学反应相结合，可以获得一种多功能、无毒的天然材料家族，具有广泛的物理和机械性能，在广泛的应用中产生商业前景。