STTR Phase I: Advanced and Remote Screening, Monitoring and Rehabilitation of Cognitive Health

STTR 第一阶段：认知健康的高级远程筛查、监测和康复

• 批准号: 1648907
• 负责人: Debraj De
• 金额: $ 22.5万
• 依托单位: Smart Health Beacons, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1648907&HistoricalAwards=false
• 关键词: STTR; Phase; Advanced; Remote; Screening

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to improve and automate cognitive health screening mechanisms used in hospital facilities, by designing and validating a smart chair and a smart wearable based health data-centric novel solution. U.S. population has more than 16 million people (this is rapidly growing further) living with cognitive impairment. There is alarming fact that people with cognitive impairment report more than three times as many hospital stays as individuals with other health conditions. These are driving development of improved cognitive health assessment solutions, that will detect subtle signs of cognitive decline early in daily life. Motivated by these markets in demand, this project is designed to develop a system for advanced and remote screening and monitoring of cognitive health, and also enabling gamified user interaction for cognitive rehabilitation. The developed technology has large potential to help elderly people prone to levels of dementia (from mild cognitive impairment to Alzheimer's disease), and slowly rehabilitating patients dealing with cognitive decline (stroke survivors and cancer patients under treatment). The designed platform and cognitive scoring algorithms developed in this project will be tested and validated with real patient study at hospital facility.The proposed project is a research, development and clinical studies effort to design and validate an advanced and remote screening, monitoring and rehabilitation solution for cognitive health. Such cognitive health management system will be achieved by technological innovation in multi-modal sensing and machine learning based behavioral data analytics from a smart chair and a custom wearable device (used separately), along with cognitive psychology driven gamified interactions and interventions. The smart chair system will capture patient non-verbal response and stress patterns, when answering to cognitive questionnaire. The smart wearable system (used with a few custom Bluetooth beacons in proximity) will analyze normalcy, forgetfulness, confusion in patient, while performing daily life cognitive tasks (such as baking a cake or cookie) in home-like kitchen facility in hospital. The main research objective includes two novel cognitive health scoring mechanism from user response with chair based cognitive questionnaire, and wearable based cognitive task performance quality. It will also design user interactions and interventions for cognitive rehabilitation and behavior reinforcement. This is a very impactful project with team's direct ongoing collaboration with hospital and neurologist, and access to large number of patients with range of cognitive disabilities (in accordance with IRB and HIPAA compliance).

这个小企业技术转让（STTR）第一阶段项目的更广泛的影响/商业潜力是通过设计和验证智能椅子和基于智能可穿戴设备的以健康数据为中心的新型解决方案，改善和自动化医院设施中使用的认知健康筛查机制。美国人口中有超过1600万人（这一数字还在迅速增长）患有认知障碍。令人震惊的事实是，患有认知障碍的人报告的住院时间是患有其他健康状况的人的三倍多。这些正在推动改进的认知健康评估解决方案的发展，该解决方案将在日常生活的早期发现认知能力下降的细微迹象。受这些市场需求的推动，该项目旨在开发一种用于高级和远程筛查和监测认知健康的系统，并实现认知康复的游戏化用户交互。开发的技术具有很大的潜力，可以帮助容易患痴呆症的老年人（从轻度认知障碍到阿尔茨海默病），并慢慢康复认知能力下降的患者（中风幸存者和正在接受治疗的癌症患者）。本项目中开发的设计平台和认知评分算法将在医院设施中进行真实的患者研究测试和验证。拟议项目是一项研究，开发和临床研究工作，旨在设计和验证先进的远程筛查，监测和认知健康康复解决方案。这种认知健康管理系统将通过智能椅子和定制可穿戴设备（单独使用）的多模态传感和基于机器学习的行为数据分析技术创新，沿着认知心理学驱动的游戏化互动和干预来实现。智能座椅系统将在回答认知问卷时捕获患者的非语言反应和压力模式。智能可穿戴系统（与附近的一些定制蓝牙信标一起使用）将分析患者的正常状态，健忘，混乱，同时在医院的家庭厨房设施中执行日常生活认知任务（如烘焙蛋糕或饼干）。主要研究目标包括两个新的认知健康评分机制，从用户的反应与椅子上的认知问卷，和可穿戴的认知任务的性能质量。它还将设计用于认知康复和行为强化的用户交互和干预措施。这是一个非常有影响力的项目，团队与医院和神经科医生直接持续合作，并接触大量患有各种认知障碍的患者（根据IRB和HIPAA合规性）。