CAREER: Nonmetal Phosphorus Catalysts for Hydrogen Transfer Reactivity

职业：用于氢转移反应的非金属磷催化剂

• 批准号: 1724505
• 负责人: Alexander Radosevich
• 金额: $ 27.22万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-10-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1724505&HistoricalAwards=false
• 关键词: CAREER; Nonmetal; Phosphorus; Catalysts; Hydrogen

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Alexander Radosevich of The Pennsylvania State University is investigating inexpensive nonmetal compounds for hydrogen transfer catalysis. Geometrically distorted tricoordinate phosphorus compounds are prepared and evaluated for transfer hydrogenation catalysis via pentacoordinate dihydridophosphorane intermediates. The research involves an investigation of the mechanistic factors that permit hydrogen transfer reactivity with phosphorus-based catalysts and an assessment of the molecular and electronic design principles required to develop efficient nonmetal catalysts for valuable synthetic transformations. In conjunction with local partners, outreach efforts to promote active participation in science by K-12 students are being pursued including a summer research curriculum for high school students from underserved populations, and a chemistry-focused, interactive children's museum exhibit for young learners. The broader impacts of this work include potential benefits from the discovery of catalysts from less toxic, earth abundant elements as well as the introduction of students to active learning in science through non-classroom activities. Catalysts enable the preparation of medicines, materials and fuels in a scalable, economical, and environmentally responsible manner. This project focuses on the discovery of a new class of catalysts based on lightweight, inexpensive, and abundant nonmetal elements. The potential broader societal benefits include the production of chemicals and materials free of residual metals and in a sustainable manner.

在这项由化学系化学催化计划资助的项目中，宾夕法尼亚州立大学的亚历山大·拉多塞维奇教授正在研究廉价的非金属化合物用于氢转移催化。制备了几何扭曲的三配位磷化合物，并对五配位二氢磷中间体的转移加氢催化性能进行了评价。这项研究包括对允许与磷基催化剂进行氢转移反应的机理因素的调查，以及对开发用于有价值的合成转化的高效非金属催化剂所需的分子和电子设计原则的评估。与当地合作伙伴一道，正在开展外联工作，以促进K-12年级学生积极参与科学活动，包括为服务不足人群的高中生开设暑期研究课程，以及为少年儿童学习者举办以化学为重点的互动儿童博物馆展览。这项工作的更广泛影响包括从毒性较低、富含稀土的元素中发现催化剂的潜在好处，以及通过非课堂活动引导学生积极学习科学。催化剂能够以可扩展、经济和对环境负责的方式制备药物、材料和燃料。该项目致力于发现一种基于轻质、廉价和丰富的非金属元素的新型催化剂。潜在的更广泛的社会效益包括以可持续的方式生产无残留金属的化学品和材料。