Bacterial monooxygenases as new biocatalysts

细菌单加氧酶作为新的生物催化剂

• 批准号: DP0877315
• 负责人: A/Prof Andrew Holmes
• 金额: $ 16.66万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877315
• 关键词: Bacterial; monooxygenases; new; biocatalysts

Using enzymes for synthesis of new pharmaceuticals is of increasing importance. Monooxygenases are particularly interesting because of their capacity to perform chemically difficult reactions thus increasing potential to make new pharmaceuticals. We have shown that an enormous pool of diverse and novel monooxygenases exists in naturally occurring bacteria. These enzymes are naturally important in pollutant degradation and regulating the emissions of greenhouse gases. We will develop these enzymes for biotechnology by characterizing structural features that influence catalytic properties relevant to challenges in pharmaceutical synthesis. The outcomes will enable their engineering for specific applications in synthesis of new drugs.

利用酶来合成新的药物越来越重要。单加氧酶特别令人感兴趣，因为它们能够进行化学上困难的反应，从而增加了制造新药的潜力。我们已经表明，在天然存在的细菌中存在大量不同的新型单加氧酶。这些酶在污染物降解和调节温室气体排放方面具有天然重要性。我们将通过表征影响与药物合成挑战相关的催化特性的结构特征来开发这些生物技术酶。 这些成果将使它们的工程在新药合成中的具体应用。