RUI: Unusual Oxidation and Domino Reactions via Palladium-catalyzed α-Heteroarylation of Ketones

通过钯催化的酮的α-杂芳基化的不寻常的氧化和多米诺反应使用钯催化剂制备有机化学品在基础研究和工业中的重要性不断增长。由钯催化的反应非常有用，并用于许多不同的化学领域，如基础化学品、染料、有机发光二极管、作物保护化学品和药剂。为了进一步改进和扩展这些催化反应，必须对基础化学进行基本了解，以发现新的化学转化，产生更少的副产物，并产生更少的废物。在这个项目中，马莉莉博士正在研究两种类型的钯催化，氧化和多米诺（顺序反应步骤）反应。光谱技术被用来理解这些反应的基本步骤，它们在绿色化学、配体设计、生物化学和药物化学中的应用也正在探索中。马博士积极参与STEM研究活动，如国际暑期研究实习生计划和UR-STEM暑期研究计划，为以前没有研究经验的学生提供服务。马博士还积极参与STEM外展活动，如小学生STEM日，STEM博览会日和周六奖励知识获取计划（SPARK），以改善小学和高中生的教育。在化学部化学催化项目的资助下，北方肯塔基州大学的Lili Ma博士正在开发钯催化剂，用于通过酮的直接α-杂芳基化进行的不寻常的氧化反应和多米诺反应。研究的第一个反应是Pd催化的微波辅助合成1，2-二酮。1，2-二酮产品可用于合成杂环、二胺和二亚胺等多种结构单元。研究的第二个反应是Pd催化的微波辅助下，一锅多米诺骨牌法合成杂芳基异香豆素衍生物。这些有效的有机反应提供了方便的途径，这些结构单元可用于从材料化学到药物化学的应用。催化循环的研究正在使用1H和31 P NMR技术进行探测，以深入了解反应机理。马博士是STEM研究和外展计划的积极参与者。为了支持该项目的更广泛的影响，她的研究活动与部门和大学STEM计划一起提供机会，招募和留住女学生，第一代大学生和非裔美国人/拉丁裔研究生在STEM学科。

Unusual Oxidation and Domino Reactions via Palladium-catalyzed alpha-Heteroarylation of KetonesThe preparation of organic chemicals using palladium catalysts continues to grow in importance in both fundamental research and industry. Reactions catalyzed by palladium are extremely useful and used in many different fields of chemistry such as basic chemicals, dyes, organic light emitting diodes, crop protection chemicals, and pharmaceutical agents. To further improve and expand these catalytic reactions, it is imperative to develop a fundamental understanding of the underlying chemistry in order to discover new chemical transformations, produce fewer byproducts, and generate less waste. In this project, Dr. Lili Ma is investigating two types of palladium-catalysis, oxidations and domino (sequential reaction steps) reactions. Spectroscopic techniques are being used to understand the fundamental steps of these reactions, and their applications in green chemistry, ligand design, biochemistry, and medicinal chemistry are also being explored. Dr. Ma is actively engaged in STEM research activities such as an international summer research intern program and UR-STEM summer research program for students without previous research experience. Dr. Ma is also highly involved in STEM outreach activities such as the STEM day for grade school students, STEM expo day, and the Saturday Program for Access to Rewarding Knowledge (SPARK) to improve the education for grade school and high school students. With funding from the Chemical Catalysis Program of the Chemistry Division, Dr. Lili Ma of Northern Kentucky University is developing palladium catalysts for unusual oxidation reactions and domino reactions via direct á-heteroarylation of ketones. The first reaction under investigation is a Pd-catalyzed, microwave-assisted synthesis of 1,2-diketones. The 1,2-diketone products are applied to the synthesis of versatile building blocks which include heterocyclic rings, diamines and diimines. The second reaction under investigation is a Pd-catalyzed microwave-assisted, one-pot domino approach for the synthesis of heteroaryl isocoumarin derivatives. These efficient organic reactions provide convenient access to building blocks which are useful for applications ranging from materials chemistry to medicinal chemistry. Studies of the catalytic cycle are being probed using 1H and 31P NMR techniques to gain insights on the reaction mechanisms. Dr. Ma is an active participant in the STEM research and outreach programs. In support of the broader impacts of the project, her research activities in conjunction with the department and university STEM programs provide opportunities to recruit and retain female students, first-generation college students and African American/Latino research students in the STEM disciplines.