RUI: Unusual Oxidation and Domino Reactions via Palladium-catalyzed α-Heteroarylation of Ketones

钯催化酮的α -杂芳基化引起的异常氧化和多米诺反应使用钯催化剂制备有机化学品在基础研究和工业上的重要性不断增加。钯催化的反应非常有用，并用于许多不同的化学领域，如基础化学品、染料、有机发光二极管、作物保护化学品和药物制剂。为了进一步改进和扩大这些催化反应，必须对潜在的化学有一个基本的了解，以便发现新的化学转化，产生更少的副产物，产生更少的废物。在这个项目中，马丽丽博士正在研究两种类型的钯催化，氧化和多米诺（顺序反应步骤）反应。光谱学技术正被用于了解这些反应的基本步骤，它们在绿色化学、配体设计、生物化学和药物化学方面的应用也在探索中。马博士积极参与STEM研究活动，如国际暑期研究实习生计划和UR-STEM暑期研究计划，为没有研究经验的学生提供研究。马博士也积极参与STEM外展活动，如STEM小学生日、STEM博览会日和周六获得奖励知识计划（SPARK），以改善小学和高中学生的教育。在化学部化学催化项目的资助下，北肯塔基大学的Lili Ma博士正在开发钯催化剂，通过酮的直接á-heteroarylation用于不寻常的氧化反应和多米诺反应。研究中的第一个反应是pd催化，微波辅助合成1,2-二酮。1,2-二酮产品应用于合成包括杂环、二胺和二胺在内的多功能构建块。第二个正在研究的反应是一种pd催化微波辅助的一锅多米诺骨牌法，用于合成异香豆素的异芳基衍生物。这些有效的有机反应为从材料化学到药物化学的应用提供了方便的构建模块。利用1H和31P核磁共振技术对催化循环进行了研究，以深入了解反应机理。马博士积极参与STEM研究和推广项目。为了支持该项目更广泛的影响，她的研究活动与系里和大学的STEM项目一起，为招收和留住STEM学科的女学生、第一代大学生和非裔美国人/拉丁裔研究学生提供了机会。

Unusual Oxidation and Domino Reactions via Palladium-catalyzed alpha-Heteroarylation of KetonesThe preparation of organic chemicals using palladium catalysts continues to grow in importance in both fundamental research and industry. Reactions catalyzed by palladium are extremely useful and used in many different fields of chemistry such as basic chemicals, dyes, organic light emitting diodes, crop protection chemicals, and pharmaceutical agents. To further improve and expand these catalytic reactions, it is imperative to develop a fundamental understanding of the underlying chemistry in order to discover new chemical transformations, produce fewer byproducts, and generate less waste. In this project, Dr. Lili Ma is investigating two types of palladium-catalysis, oxidations and domino (sequential reaction steps) reactions. Spectroscopic techniques are being used to understand the fundamental steps of these reactions, and their applications in green chemistry, ligand design, biochemistry, and medicinal chemistry are also being explored. Dr. Ma is actively engaged in STEM research activities such as an international summer research intern program and UR-STEM summer research program for students without previous research experience. Dr. Ma is also highly involved in STEM outreach activities such as the STEM day for grade school students, STEM expo day, and the Saturday Program for Access to Rewarding Knowledge (SPARK) to improve the education for grade school and high school students. With funding from the Chemical Catalysis Program of the Chemistry Division, Dr. Lili Ma of Northern Kentucky University is developing palladium catalysts for unusual oxidation reactions and domino reactions via direct á-heteroarylation of ketones. The first reaction under investigation is a Pd-catalyzed, microwave-assisted synthesis of 1,2-diketones. The 1,2-diketone products are applied to the synthesis of versatile building blocks which include heterocyclic rings, diamines and diimines. The second reaction under investigation is a Pd-catalyzed microwave-assisted, one-pot domino approach for the synthesis of heteroaryl isocoumarin derivatives. These efficient organic reactions provide convenient access to building blocks which are useful for applications ranging from materials chemistry to medicinal chemistry. Studies of the catalytic cycle are being probed using 1H and 31P NMR techniques to gain insights on the reaction mechanisms. Dr. Ma is an active participant in the STEM research and outreach programs. In support of the broader impacts of the project, her research activities in conjunction with the department and university STEM programs provide opportunities to recruit and retain female students, first-generation college students and African American/Latino research students in the STEM disciplines.