Research Initiation Award: Mechanisms regulating intrinsic levels of antimicrobial resistance in planktonic cells and biofilms of commensal Neisseria

研究启动奖：调节浮游细胞和共生奈瑟菌生物膜中抗菌素耐药性内在水平的机制

• 批准号: 1800691
• 负责人: Maira Goytia
• 金额: $ 14.95万
• 依托单位: Spelman College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-15 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1800691&HistoricalAwards=false
• 关键词: Research; Initiation; Award; Mechanisms; regulating

Catalyst Projects provide support for Historically Black Colleges and Universities to work towards establishing research capacity of faculty to strengthen science, technology, engineering and mathematics undergraduate education and research. It is expected that the award will further the faculty member's research capability, improve research and teaching at the institution, and involve undergraduate students in research experiences. The award to Spelman College aims to characterize commensal Neisseria levels and mechanisms of antimicrobial resistance, in planktonic cells and cells forming biofilms, and whether these bacteria should be considered a reservoir for the spread of antimicrobial resistance genes.Commensal bacteria persist inside or outside multicellular organisms, usually without causing harm. Several commensal Neisseria species live in the human oral and nasopharynx as part of a complex and diverse microbiome. They are related to the pathogenic N. meningitidis, an agent of meningitis, and N. gonorrhoeae, the agent of the sexually-transmitted disease gonorrhea. As much as pathogenic Neisseria are studied, commensal Neisseria are poorly characterized. Deciphering the factors and regulatory pathways affecting antimicrobial resistance in commensal Neisseria will elucidate the molecular mechanisms that evolved in commensal and pathogenic species. The goals of this study are to characterize antimicrobial resistance levels of planktonic cells, of cells in biofilms, and to identify the factors and regulatory mechanisms involved in antimicrobial resistance in these cell populations of commensal Neisseria species.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

催化剂项目为历史上的黑人学院和大学提供支持，努力建立教师的研究能力，以加强科学，技术，工程和数学本科教育和研究。预计该奖项将进一步提高教师的研究能力，改善研究和教学机构，并参与本科生的研究经验。该奖项授予斯佩尔曼学院的目的是表征细菌内奈瑟氏球菌的耐药性水平和机制，在增殖细胞和形成生物膜的细胞中，以及这些细菌是否应该被视为耐药性基因传播的储存库。共生细菌在多细胞生物体内部或外部存在，通常不会造成伤害。几种口腔奈瑟氏菌物种生活在人类口腔和鼻咽中，作为复杂多样的微生物组的一部分。它们与病原菌N.脑膜炎，脑膜炎的病原体，和N.淋病，性传播疾病淋病的病原体。尽管对致病性奈瑟菌进行了大量的研究，但对细菌性奈瑟菌的特征描述很少。阐明影响奈瑟氏球菌耐药性的因素和调控途径，将有助于阐明奈瑟氏球菌和致病菌的分子机制。本研究的目的是表征细菌细胞的抗菌素耐药性水平，生物膜中的细胞，并确定这些细胞群体中的耐药性的因素和调控机制，这些细胞群体的细菌奈瑟氏菌species.This奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。