Research Initiation Award: Spatial organization and temporal coordination involved in secretory vesicle trafficking and exocytosis in live cells

研究启动奖：活细胞分泌囊泡运输和胞吐作用中涉及的空间组织和时间协调

• 批准号: 1801204
• 负责人: Dinari Harris
• 金额: $ 29.66万
• 依托单位: Howard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1801204&HistoricalAwards=false
• 关键词: Research; Initiation; Award; Spatial; organization

Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing programs. It is expected that the award helps to further the faculty member's research capability and effectiveness, improves research and teaching at the home institution, and involves undergraduate students in research experiences. The award to Howard University aims to reveal how spatiotemporal information is integrated and used by cells to affect signaling pathways promoting expulsion of substances from cells (exocytosis) and will enable researchers to better understand how exocytosis allows cells to communicate with other cells, tissues, and the extracellular space. Exocytosis is a fundamental cellular behavior that is ubiquitous across eukaryotes and other cell types. The goal of this study is to provide a better understanding of how proteins, lipids, and the actin cytoskeleton network act as organizing "elements" regulating exocytosis. Fluorescence microscopy will be utilized to establish an understanding of the spatial and temporal requirements governing the biophysical principles that organize cell membranes and influence biological processes like regulated exocytosis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

研究启动奖为历史悠久的黑人学院和大学的初级和职业生涯中期教师提供支持，他们正在建立新的研究计划或重新定向和重建现有计划。预计该奖项有助于进一步提高教师的研究能力和有效性，改善所在机构的研究和教学，并让本科生参与研究经验。授予霍华德大学的这一奖项旨在揭示时空信息如何被细胞整合和利用，以影响促进物质从细胞中排出的信号通路(胞吐作用)，并使研究人员能够更好地了解胞吐作用如何使细胞与其他细胞、组织和细胞外空间进行交流。胞吐是一种基本的细胞行为，在真核生物和其他类型的细胞中普遍存在。这项研究的目的是为了更好地了解蛋白质、脂质和肌动蛋白细胞骨架网络是如何作为调节胞吐的组织元素发挥作用的。荧光显微镜将被用来建立对生物物理原理的空间和时间要求的理解，这些生物物理原理组织细胞膜并影响生物过程，如调节的胞吐。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。