Effects of Tax and p8 proteins on cell-to-cell transmission of Human T-cell lymphotropic virus type 1 (HTLV-1) (C06)

Tax 和 p8 蛋白对人类 T 细胞嗜淋巴细胞病毒 1 型 (HTLV-1) 细胞间传播的影响 (C06)

• 批准号: 233860699
• 金额: --
• 依托单位: Virologisches Institut - Klinische und Molekulare Virologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/233860699?language=en
• 关键词: Effects; Tax; p8; proteins; cell

The viral transactivator Tax-1 and the accessory protein p8 are critical for HTLV-1 cell-to-cell transmission. However, the specific virus-host interface mediating virus transmission is only poorly understood. Project C6 seeks to continue mechanistic investigations on HTLV-1 transmission which will lead to a detailed understanding of this process. Consequently, the information obtained will be transferred into translational studies aiming at the inhibition of virus transmission by the means of small molecules, nanobodies, peptide mimicking and gene editing strategies.

病毒反式激活因子Tax-1和辅助蛋白p8对HTLV-1细胞间传播至关重要。然而，介导病毒传播的特定病毒-宿主界面仅知之甚少。C6项目旨在继续对HTLV-1传播的机制进行研究，这将导致对这一过程的详细了解。因此，所获得的信息将被转移到旨在通过小分子，纳米抗体，肽模拟和基因编辑策略抑制病毒传播的翻译研究中。