NSF Workshop: Enabling biological discovery through innovations in imaging and computation; MBL; April/May, 2018

NSF 研讨会：通过成像和计算创新实现生物发现；

• 批准号: 1821881
• 负责人: Rudolf Oldenbourg
• 金额: $ 9.8万
• 依托单位: Marine Biological Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1821881&HistoricalAwards=false
• 关键词: NSF; Workshop; Enabling; biological; discovery

Our ability to image live cells, organs, and whole organisms has been transformed by recent improvements in light microscopy and computational methods. These important advances have also underscored three critical needs in the neuroscience and broader biological community: 1) interdisciplinary, team-based approaches in developing new imaging technologies; 2) fast, accessible, and responsive deployment of technological innovations; and 3) the need for related training opportunities at the interface of biology, physics, and engineering. This workshop convenes interdisciplinary experts and trainees to brainstorm innovative and integrated approaches that create a positive feedback loop between instrument developers, computational experts, and biologists to transform the way imaging technologies are developed and deployed. The workshop is focused on discussing approaches that 1) increase access and training opportunities in cutting-edge imaging instrumentation as it is being developed; 2) foster interdisciplinary collaboration and training between microscopists, computational imaging specialists, and biologists to advance innovation and discovery; and 3) promote the development of complementary platforms that enable unprecedented imaging across scales. The 2-day workshop is held at the Marine Biological Laboratory in Woods Hole, bringing together national and international key players, who work at the interface between biology, engineering, physics, and computation. The workshop includes keynote speakers, special sessions on "Building and disseminating new microscopy methods", "Computation for generating image data and their analysis", "Centers for interdisciplinary collaborations and training," and a podium discussion on the creation of new centers that increase access and training in cutting-edge imaging instrumentation as it is being developed. With the goal of engaging the next generation of scientists and engineers working at the interface between several disciplines, a poster and additional discussion session will provide opportunities for graduate students and postdocs to present their work and give input on components that are currently missing or underrepresented in their training and that can be met by interdisciplinary imaging centers. As diversity is key to the success of the workshop, participants include established as well as early career investigators and trainees from different nations, as well as genders and minorities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

我们对活细胞、器官和整个生物体进行成像的能力已经被光学显微镜和计算方法的最新改进所改变。这些重要的进展也强调了神经科学和更广泛的生物界的三个关键需求：1）开发新成像技术的跨学科，基于团队的方法; 2）快速，可访问和响应式的技术创新部署;以及3）在生物学，物理学和工程学接口的相关培训机会的需求。该研讨会召集跨学科专家和学员集思广益，创新和综合的方法，在仪器开发人员，计算专家和生物学家之间建立一个积极的反馈循环，以改变成像技术的开发和部署方式。该研讨会重点讨论以下方法：1）增加尖端成像仪器开发过程中的获取和培训机会; 2）促进显微镜学家、计算成像专家和生物学家之间的跨学科合作和培训，以推进创新和发现;和3）促进互补平台的开发，实现前所未有的跨规模成像。为期2天的研讨会在伍兹霍尔的海洋生物实验室举行，汇集了国内和国际的主要参与者，他们在生物学，工程学，物理学和计算之间的接口工作。研讨会包括主旨发言人，关于“建立和传播新的显微镜方法”，“计算生成图像数据及其分析”，“跨学科合作和培训中心”的特别会议，以及关于创建新中心的讲台讨论，这些中心增加了尖端成像仪器的访问和培训。为了吸引下一代科学家和工程师在多个学科之间的接口工作，海报和额外的讨论会议将为研究生和博士后提供机会，展示他们的工作，并就目前在培训中缺失或代表性不足的组件提供投入，并且可以通过跨学科成像中心满足。由于多样性是研讨会成功的关键，参与者包括来自不同国家的成熟和早期职业调查人员和学员，以及性别和少数民族。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Transforming the development and dissemination of cutting-edge microscopy and computation.

• DOI: 10.1038/s41592-019-0475-y
• 发表时间: 2019-08
• 期刊: Nature methods
• 影响因子: 48
• 作者: Colón-Ramos DA;La Riviere P;Shroff H;Oldenbourg R
• 通讯作者: Oldenbourg R