NSF Workshop: Enabling biological discovery through innovations in imaging and computation; MBL; April/May, 2018

最近光学显微镜和计算方法的改进改变了我们对活细胞、器官和整个生物体成像的能力。这些重要的进展也突显了神经科学和更广泛的生物界的三个关键需求：1)开发新的成像技术的跨学科、基于团队的方法；2)快速、可获得和反应迅速的技术创新部署；以及3)需要生物、物理和工程学相结合的相关培训机会。该研讨会召集了跨学科专家和受训人员，集思广益，提出了创新和集成的方法，在仪器开发人员、计算专家和生物学家之间建立了一个积极的反馈循环，以改变成像技术的开发和部署方式。研讨会的重点是讨论以下方法：1)随着尖端成像仪器的开发，增加其获取机会和培训机会；2)促进显微镜专家、计算成像专家和生物学家之间的跨学科合作和培训，以促进创新和发现；以及3)促进互补性平台的开发，使前所未有的跨规模成像成为可能。为期两天的研讨会在伍兹霍尔的海洋生物实验室举行，聚集了国内和国际的关键人物，他们从事生物、工程、物理和计算之间的工作。研讨会包括主旨演讲者、关于“建立和传播新的显微镜方法”、“用于生成图像数据及其分析的计算”、“跨学科协作和培训中心”的特别会议，以及关于创建新中心的讲台讨论，以增加正在开发的尖端成像仪器的准入和培训。为了吸引下一代科学家和工程师在几个学科之间的接口工作，海报和额外的讨论将为研究生和博士后提供展示他们的工作的机会，并就目前在他们的培训中缺失或代表不足的部件提供意见，这些部件可以由跨学科成像中心满足。由于多样性是研讨会成功的关键，参与者包括来自不同国家的成熟和早期职业调查人员和受训人员，以及性别和少数民族。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Our ability to image live cells, organs, and whole organisms has been transformed by recent improvements in light microscopy and computational methods. These important advances have also underscored three critical needs in the neuroscience and broader biological community: 1) interdisciplinary, team-based approaches in developing new imaging technologies; 2) fast, accessible, and responsive deployment of technological innovations; and 3) the need for related training opportunities at the interface of biology, physics, and engineering. This workshop convenes interdisciplinary experts and trainees to brainstorm innovative and integrated approaches that create a positive feedback loop between instrument developers, computational experts, and biologists to transform the way imaging technologies are developed and deployed. The workshop is focused on discussing approaches that 1) increase access and training opportunities in cutting-edge imaging instrumentation as it is being developed; 2) foster interdisciplinary collaboration and training between microscopists, computational imaging specialists, and biologists to advance innovation and discovery; and 3) promote the development of complementary platforms that enable unprecedented imaging across scales. The 2-day workshop is held at the Marine Biological Laboratory in Woods Hole, bringing together national and international key players, who work at the interface between biology, engineering, physics, and computation. The workshop includes keynote speakers, special sessions on "Building and disseminating new microscopy methods", "Computation for generating image data and their analysis", "Centers for interdisciplinary collaborations and training," and a podium discussion on the creation of new centers that increase access and training in cutting-edge imaging instrumentation as it is being developed. With the goal of engaging the next generation of scientists and engineers working at the interface between several disciplines, a poster and additional discussion session will provide opportunities for graduate students and postdocs to present their work and give input on components that are currently missing or underrepresented in their training and that can be met by interdisciplinary imaging centers. As diversity is key to the success of the workshop, participants include established as well as early career investigators and trainees from different nations, as well as genders and minorities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.