MRI: Acquisition of a Transmission Electron Microscope (TEM) for Soft Materials for the Advanced Microscopy and Imaging Center (AMIC)

MRI：为高级显微镜和成像中心 (AMIC) 购买软材料透射电子显微镜 (TEM)

• 批准号: 1828300
• 负责人: Andreas Nebenfuehr
• 金额: $ 43.99万
• 依托单位: University of Tennessee Knoxville
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828300&HistoricalAwards=false
• 关键词: MRI; Acquisition; Transmission; Electron; Microscope

An award is made to the University of Tennessee Knoxville to support the acquisition of a transmission electron microscope (TEM) for the Advanced Microscopy and Imaging Center. The new TEM will be equipped for dual-axis electron tomography, which creates an unprecedented view of the three-dimensional cellular organization. The system will also be equipped with a high-resolution camera to provide a shared platform for diverse innovative projects that depend on advanced imaging capabilities. Most of the research on this instrument will be carried out by graduate students and postdoctoral researchers who will gain expertise in modern techniques of high-resolution imaging. The new system will also be the core instrument for advanced imaging course, where students receive research training with significant hands-on time on the TEM. The new instrument will support research projects aimed at deciphering the formation of cell-cell connections in plants, understanding the interactions between bacteria and their animal or plant hosts, and how chromosomes move during different parts of the cell cycle. Other projects will investigate the molecular mechanism of protein import into different cell organelles, or analyze the morphology and assembly of viruses. Researchers in the Chemistry Department will use the instrument to study the nanostructure of advanced materials with a wide range of potential applications. Results from these studies will be published in peer-reviewed scientific journals, presented at scientific meetings, and used in public outreach or education events.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

田纳西大学诺克斯维尔获得了一个奖项，以支持高级显微镜和成像中心购买透射电子显微镜（TEM）。新的TEM将配备双轴电子断层扫描，这创造了一个前所未有的三维细胞组织的看法。该系统还将配备高分辨率摄像头，为依赖先进成像能力的各种创新项目提供共享平台。该仪器的大部分研究将由研究生和博士后研究人员进行，他们将获得高分辨率成像现代技术的专业知识。新系统也将成为高级成像课程的核心仪器，学生将在TEM上接受大量实践时间的研究培训。新仪器将支持旨在破译植物细胞间连接形成的研究项目，了解细菌与其动物或植物宿主之间的相互作用，以及染色体在细胞周期的不同部分如何移动。其他项目将研究蛋白质输入不同细胞器的分子机制，或分析病毒的形态和组装。化学系的研究人员将使用该仪器研究具有广泛潜在应用的先进材料的纳米结构。这些研究的结果将发表在同行评审的科学期刊上，在科学会议上发表，并用于公共宣传或教育活动。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

项目成果

Calcium-Responsive Liposomes via a Synthetic Lipid Switch

• DOI: 10.1002/chem.201705810
• 发表时间: 2018-03-07
• 期刊: CHEMISTRY-A EUROPEAN JOURNAL
• 影响因子: 4.3
• 作者: Lou, Jinchao;Carr, Adam J.;Best, Michael D.
• 通讯作者: Best, Michael D.

Homburgvirus LP-018 Has a Unique Ability to Infect Phage-Resistant Listeria monocytogenes

Homburgvirus LP-018 具有感染噬菌体抗性单核细胞增生李斯特菌的独特能力

• DOI: 10.3390/v11121166
• 发表时间: 2019
• 期刊: Viruses
• 作者: Song, YaxiongPeters

Elongated PEO-based nanoparticles bind the high-density lipoprotein (HDL) receptor scavenger receptor class B I (SR-BI)

• DOI: 10.1016/j.jconrel.2021.07.045
• 发表时间: 2021-08-06
• 期刊: JOURNAL OF CONTROLLED RELEASE
• 影响因子: 10.8
• 作者: Raith，Mitch;Kauffman，Sarah J.;Dalhaimer，Paul
• 通讯作者: Dalhaimer，Paul

Complete Genome Sequences and Transmission Electron Micrographs of Listeria Phages of the Genus Homburgvirus

洪堡病毒属李斯特菌噬菌体的完整基因组序列和透射电子显微照片

• DOI: 10.1128/mra.00825-19
• 发表时间: 2019
• 期刊: Microbiology Resource Announcements
• 影响因子: 0.8
• 作者: Hudson, Lauren K.;Peters, Tracey L.;Song, Yaxiong;Denes, Thomas G.;Dennehy, John J.
• 通讯作者: Dennehy, John J.

Reactive Oxygen Species-Responsive Liposomes via Boronate-Caged Phosphatidylethanolamine

• DOI: 10.1021/acs.bioconjchem.0c00397
• 发表时间: 2020-09-01
• 期刊: BIOCONJUGATE CHEMISTRY
• 影响因子: 4.7
• 作者: Lou, Jinchao;Best, Michael D.
• 通讯作者: Best, Michael D.