STTR Phase I: Development of a coral reef-friendly sunscreen with broad spectrum protection

这个小企业创新研究（SBIR/STTR）第一阶段项目的更广泛的影响/商业潜力是商业化的世界？这是世界上第一款防晒霜，它可以防止UVA引起的光老化，提供足够的UVB保护，逆转UVB引起的损害，对珊瑚礁安全。目前市场上的主要防晒霜已被证明不足以保护免受UVA损伤（光老化）。此外，在80%以上的化学防晒剂中发现的氧苯酮和奥西诺酯已被证明对珊瑚细胞具有高度毒性。估计有14,000吨防晒霜流入世界？每年都有大量的珊瑚礁被破坏，而这些防晒霜中含有的氧苯酮会导致珊瑚白化，加速世界的毁灭。已经很脆弱的珊瑚礁。Magic Blue防晒霜使用替代的环保技术来保护皮肤免受UVA和UVB的伤害，Magic Blue防晒霜的成功商业化/市场采用将通过保护我们的水生生态系统，特别是珊瑚礁，使其免受氧苯酮/奥西诺酯引起的进一步损害，从而显着造福于全球环境。这个小型企业创新研究（SBIR/STTR）第一阶段项目将开发一种新型的珊瑚礁友好防晒霜，可以提供广谱保护。Magic Blue，LLC与马里兰州大学帕克分校合作，并与卡内基科学研究所合作进行关键的可行性实验，包括2D和3D人体皮肤组织中UVA防护的生物分析，SPF测定的化学分析，以及新防晒霜对软珊瑚礁和硬珊瑚礁影响的环境研究。 一旦这些实验完成，该项目的第二阶段将围绕获得必要的FDA批准进行商业发布。一个成功的STTR项目的总体结果将是世界的商业化？这是NSF的第一款防晒霜，它将包含以下属性：科学证明可以防止UVA引起的光老化，能够提供足够的UVB保护并逆转UVB引起的损害，对珊瑚礁安全。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR/STTR) Phase I project is to commercialize the world?s first sunscreen that protects against UVA-induced photoaging, provides sufficient UVB protection and to reverse UVB-induced damage, and is safe to coral reefs. Leading sunscreens that are currently on the market have been shown to be inadequate in protection against UVA damage (photoaging). Moreover, Oxybenzone and octinoxate, which are found in over 80% of chemical sunscreens, have been shown to be highly toxic to coral cells. Estimated 14,000 tons of sunscreen settle into the world?s coral reefs every year and the oxybenzone that is present in many of these sunscreens cause coral bleaching and accelerate the destruction of the world?s already fragile coral reefs. The Magic Blue sunscreen uses an alternative eco-friendly technology to protect the skin from UVA and UVB damage, and the successful commercialization/market adoption of the Magic Blue sunscreen will significantly benefit the global environment by protecting our aquatic ecosystems, especially coral reefs, from further oxybenzone/octinoxate-induced damage. This Small Business Innovation Research (SBIR/STTR) Phase I project will develop a novel coral reef-friendly sunscreen that can provide broad spectrum protection. Magic Blue, LLC is partnering with the University of Maryland, College Park and collaborating with the Carnegie Institution for Science to conduct the key feasibility experiments, including biological analysis of UVA protection in 2D and 3D human skin tissues, chemical assays on SPF determination, and environmental study on the effects of the new sunscreen on soft and hard coral reefs. Once these experiments are complete, Phase II of the project will revolve around obtaining necessary FDA approval for commercial launch. The overall outcome from a successful STTR project will be the commercialization of the world?s first sunscreen that will encompass the following attributes: scientifically proven to protect against UVA-induced photoaging, abilities to provide sufficient UVB protection and to reverse UVB-induced damage, and safe to coral reefs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.