STTR Phase I: Development of a coral reef-friendly sunscreen with broad spectrum protection

STTR 第一阶段：开发具有广谱保护的珊瑚礁友好型防晒霜

• 批准号: 1842745
• 负责人: Jasmin El Kordi
• 金额: $ 22.5万
• 依托单位: MAGIC BLUE, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1842745&HistoricalAwards=false
• 关键词: STTR; Phase; Development; coral; reef

The broader impact/commercial potential of this Small Business Innovation Research (SBIR/STTR) Phase I project is to commercialize the world?s first sunscreen that protects against UVA-induced photoaging, provides sufficient UVB protection and to reverse UVB-induced damage, and is safe to coral reefs. Leading sunscreens that are currently on the market have been shown to be inadequate in protection against UVA damage (photoaging). Moreover, Oxybenzone and octinoxate, which are found in over 80% of chemical sunscreens, have been shown to be highly toxic to coral cells. Estimated 14,000 tons of sunscreen settle into the world?s coral reefs every year and the oxybenzone that is present in many of these sunscreens cause coral bleaching and accelerate the destruction of the world?s already fragile coral reefs. The Magic Blue sunscreen uses an alternative eco-friendly technology to protect the skin from UVA and UVB damage, and the successful commercialization/market adoption of the Magic Blue sunscreen will significantly benefit the global environment by protecting our aquatic ecosystems, especially coral reefs, from further oxybenzone/octinoxate-induced damage. This Small Business Innovation Research (SBIR/STTR) Phase I project will develop a novel coral reef-friendly sunscreen that can provide broad spectrum protection. Magic Blue, LLC is partnering with the University of Maryland, College Park and collaborating with the Carnegie Institution for Science to conduct the key feasibility experiments, including biological analysis of UVA protection in 2D and 3D human skin tissues, chemical assays on SPF determination, and environmental study on the effects of the new sunscreen on soft and hard coral reefs. Once these experiments are complete, Phase II of the project will revolve around obtaining necessary FDA approval for commercial launch. The overall outcome from a successful STTR project will be the commercialization of the world?s first sunscreen that will encompass the following attributes: scientifically proven to protect against UVA-induced photoaging, abilities to provide sufficient UVB protection and to reverse UVB-induced damage, and safe to coral reefs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR/STTR）第一阶段项目的更广泛的影响/商业潜力是将世界商业化？这是第一款可以防止uva引起的光老化的防晒霜，提供足够的UVB保护并逆转UVB引起的损伤，并且对珊瑚礁是安全的。目前市场上的主要防晒霜已被证明不足以防止UVA伤害（光老化）。此外，在80%以上的化学防晒霜中发现的氧苯酮和桂皮酸盐已被证明对珊瑚细胞有剧毒。估计有14000吨防晒霜落在这个世界上？许多防晒霜中含有的氧苯酮会导致珊瑚白化，加速世界的毁灭？我们已经脆弱的珊瑚礁。Magic Blue防晒霜使用了一种替代的环保技术来保护皮肤免受UVA和UVB的伤害，Magic Blue防晒霜的成功商业化/市场采用将通过保护我们的水生生态系统，特别是珊瑚礁，进一步免受氧苯酮/辛酸盐引起的损害，从而显著造福全球环境。这个小企业创新研究（SBIR/STTR）第一阶段项目将开发一种新型的珊瑚礁友好型防晒霜，可以提供广谱保护。Magic Blue有限责任公司正在与马里兰大学帕克分校合作，并与卡内基科学研究所合作进行关键的可行性实验，包括对2D和3D人体皮肤组织中UVA防护的生物学分析，SPF测定的化学分析，以及新防晒霜对软珊瑚礁和硬珊瑚礁影响的环境研究。一旦这些实验完成，该项目的第二阶段将围绕获得必要的FDA批准进行商业发射。一个成功的STTR项目的总体结果将是世界商业化？这是第一款包含以下属性的防晒霜：科学证明可以防止uva引起的光老化，能够提供足够的UVB保护并逆转UVB引起的伤害，并且对珊瑚礁安全。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。