Research Initiation Award: Search for the Epigenomic Mechanisms of Paternal Inheritance of Aggression in Social Honeybees

研究启动奖：寻找社会性蜜蜂攻击性父系遗传的表观基因组机制

• 批准号: 1900793
• 负责人: Hongmei Li-Byarlay
• 金额: $ 30万
• 依托单位: Central State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1900793&HistoricalAwards=false
• 关键词: Research; Initiation; Award; Search; Epigenomic

Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing programs. It is expected that the award helps to further the faculty member's research capability and effectiveness, improves research and teaching at the home institution, and involves undergraduate students in research experiences. The award to Central State University seeks to determine the epigenetic modifications and epigenomic architecture connecting aggressive behavior of honeybees to their sociogenome.To investigate the potential imprinting mechanisms via parental inheritance, the project will focus on the quantification analysis of epigenetic marks in the brain of Africanized and European honey bees. The use of modern epitranscriptomic and genomic approaches will reveal the molecular regulation of behavioral epigenomics. These studies will provide new insights and the first evidence of how epigenetic marks regulate or link to the process of transcription, gene regulation, or molecular evolution. A new field of behavioral epigenetics and epigenomics will also be developed using social honey bees as a model system.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

研究启动奖为传统黑人学院和大学的初级和中期职业教师提供支持，他们正在建立新的研究项目或重新指导和重建现有项目。期望该奖项有助于提高教师的研究能力和效率，改善所在机构的研究和教学，并使本科生参与研究经验。该奖项授予中央州立大学，旨在确定将蜜蜂的攻击行为与其社会基因组联系起来的表观遗传修饰和表观基因组结构。为了研究通过亲代遗传的潜在印记机制，该项目将重点对非洲化和欧洲化蜜蜂大脑中的表观遗传标记进行量化分析。现代表观转录组学和基因组学方法的应用将揭示行为表观基因组学的分子调控。这些研究将为表观遗传标记如何调节或连接转录、基因调控或分子进化过程提供新的见解和第一个证据。以群居蜜蜂为模型系统的行为表观遗传学和表观基因组学的新领域也将得到发展。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。