The pathophysiologic role of the M-type phospholipaseA2 receptor in membranous glomerulonephritis.

M型磷脂酶A2受体在膜性肾小球肾炎中的病理生理作用。

• 批准号: 237519514
• 负责人: Professor Dr. Rolf A.K. Stahl (†)
• 金额: --
• 依托单位: Institut für Pathologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/237519514?language=en
• 关键词: pathophysiologic; role; type; phospholipaseA2; receptor

Recently, the M-type phospholipase A2 receptor-1 (PLA2R) was discovered as a potential important glomerular antigen in primary membranous glomerulonephritis (MN) that strongly improves diagnosis and therapy. However, the antigenic effect as well as the pathophysiologic role of PLA2R on podocytes in the course of MN are currently unknown. By using inducible podocyte-specific transgenic PLA2R mice, we plan to establish a murine MN-model either through an active immunization of the mice with PLA2R antigen or through a passive immunization with PLA2R antibodies. Furthermore, an experimental therapy is planned by application of different forms of soluble PLA2R domains in nephritic mice. We hope this study will contribute to a better understanding in the pathophysiology of MN and their underlying therapeutic options.

近年来，M型磷脂酶A2受体1（PLA2R）被发现是原发性膜性肾小球肾炎（MN）的一个潜在的重要肾小球抗原，极大地提高了MN的诊断和治疗。然而，在MN的过程中，PLA2R对足细胞的抗原效应以及病理生理作用目前尚不清楚。通过使用可诱导足细胞特异性转基因PLA2R小鼠，我们计划通过用PLA2R抗原主动免疫小鼠或通过用PLA2R抗体被动免疫小鼠来建立小鼠MN模型。此外，计划通过在肾炎小鼠中应用不同形式的可溶性PLA2R结构域来进行实验性治疗。我们希望这项研究将有助于更好地了解MN的病理生理学及其潜在的治疗选择。