The pathophysiologic role of the M-type phospholipaseA2 receptor in membranous glomerulonephritis.

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Recently, the M-type phospholipase A2 receptor-1 (PLA2R) was discovered as a potential important glomerular antigen in primary membranous glomerulonephritis (MN) that strongly improves diagnosis and therapy. However, the antigenic effect as well as the pathophysiologic role of PLA2R on podocytes in the course of MN are currently unknown. By using inducible podocyte-specific transgenic PLA2R mice, we plan to establish a murine MN-model either through an active immunization of the mice with PLA2R antigen or through a passive immunization with PLA2R antibodies. Furthermore, an experimental therapy is planned by application of different forms of soluble PLA2R domains in nephritic mice. We hope this study will contribute to a better understanding in the pathophysiology of MN and their underlying therapeutic options.